CAS: 873310-33-9; N-Methyl-3-Phenoxy-3-Phenylpropan-1-Amine Hydrochloride

英文名称N-Methyl-3-Phenoxy-3-Phenylpropan-1-Amine Hydrochloride
中文名称N-甲基-3-苯氧基-3-苯基丙-1-胺盐酸盐
IUPAC名称N-methyl-3-phenoxy-3-phenylpropan-1-amine hydrochloride
其它别名Atomoxetine Hydrochloride Ep Impurity A; Atomoxetine Impurity 1(Atomoxetine Ep Impurity A); Atomoxetine Hydrochloride Impurities; N-Methyl-3-Phenoxy-3-Phenylpropan-1-Amine Hydrochloride; Atomoxetine Hydrochloride Impurity A; Atomoxetine Ep Impurity A Hcl; N-Methyl-3-Phenoxy-3-Phenyl-Propylamine Hydrochloride; Atomoxetine Ep Impurity An-Methyl-3-Phenoxy-3-Phenylpropan-1-Amine Hydrochloride
CAS编号873310-33-9
MFCD编号:MFCD26385662
分子式:C16H20ClNO分子量:277.8
产品CID: 1879646
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: YKLKKVGMPUCUOE-UHFFFAOYSA-N
InChI=1S/C16H19NO.ClH/c1-17-13-12-16(14-8-4-2-5-9-14)18-15-10-6-3-7-11-15;/h2-11,16-17H,12-13H2,1H3;1H
计算化学: 氢键受体数2.0氢键供体数1可旋转键数6

相似化合物

56161-70-7 1643684-06-3 873310-31-7

MSDS等安全信息

上下游产品

3-methylamino-1-phenylpropan-1-ol fluorobenzene

合成工艺路线路线简述

📜N-甲基-3-苯基-3-羟基丙胺,氟苯置于potassium Tert-Butylate,盐酸体系中,用异丁酰胺,水,甲苯作为反应溶剂,化学反应 22.0H,反应生成 N-甲基-3-苯氧基-3-苯基-丙胺盐酸盐
参考文献: Synthesis Of Atomoxetine Hydrochloride[fr] Synthese D'Hydrochlorure D'Atomoxetine
标题: Synthesis Of Atomoxetine Hydrochloride[fr] Synthese D'Hydrochlorure D'Atomoxetine
摘要:(+/-)-酒石酸阿托莫西汀ii型晶体和固体(+/-)-阿托莫西汀游离碱在制备盐酸阿托莫西汀时是有用的.

海关参考信息

2902600000-乙苯
2905121000-正丙醇
2906210000-苄醇
2908199090-其他酚的卤化衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2008004470-A1
优先权日:2004-09-27
标题:Synthesis of Atomoxetine Hydrochloride
发明人：MATHAD VIJAYAVITTHAL T; GHANTA MAHESH R; GOVINDAN SHANMUGAM; MACHARLA PRABHAKAR; NALIVELA VENU
权利人:MATHAD VIJAYAVITTHAL T; GHANTA MAHESH R; GOVINDAN SHANMUGAM; MACHARLA PRABHAKAR; NALIVELA VENU
摘要:(Â±)-Atomoxetine oxalate having crystalline Form II and a solid (Â±)-atomoxetine free base are useful in preparing atomoxetine hydrochloride.

专利号:WO-2006037055-A1
优先权日:2004-09-27
标题 :Synthesis of atomoxetine hydrochloride

专利号:EP-1794112-A1
优先权日:2004-09-27
标题 :Synthesis of atomoxetine hydrochloride

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Isolated Atomoxetine Impurity, Processes For The Preparation Of Atomoxetine Impurities And Their Use As Reference Standards
摘要:The Present Invention Provides Isolated N-Methyl-3-(3-Methylphenoxy)-3-Phenylpropylamine Hydrochloride, And Preparation Thereof As Well As Of N-Methyl-3-(4-Methylphenoxy)-3-Phenylpropylamine Hydrochloride And Of N-Methyl-3-Phenoxy-3-Phenylpropylamine Hydrochloride. The Invention Further Provides The Use Of The Above Compounds As Reference Markers And/or Reference Standards During The Synthesis Of Atomoxetine. Also Provided Is A Method Of Limiting The Amounts Of The Impurities 3Ft (3-Fluorotoluene), 4Ft (4-Fluorotoluene), And Fb (Fluorobenzene) In The 2-Fluorotoluene Starting Material Used In The Synthesis Of Atomoxetine Hydrochloride. The Purity Of The Atomoxetine Hydrochloride Product Is Ensured By Determining The Amounts Of 3Ft, 4Ft, And Fb In The 2-Fluorotoluene Starting Material With The Marker 3-Atm Hcl.