CAS: 787544-61-0; (R)-3-Amino-3-(3-Nitrophenyl)Propionic Acid

上下游产品

3-amino-3-(3-nitro-phenyl)-propionic acid (R)-3-amino-3-(3-nitrophenyl)propanoic acid hydr°Chloride (R)-ethyl 3-(3-aminophenyl)-3-(tert-butoxycarbonylamino)propanoate

3-氨基-3-(3-硝基苯基)丙酸置于phenylalanine Ammonia α-Lyase From Anabaena Variabilis,Phenylalanine Ammonia Lyase From Streptomyces Maritimus体系中,用 Aq. Buffer 作为反应溶剂,化学反应 24.0H,反应生成 (R)-3-氨基-3-(3-硝基苯基)丙酸,3-硝基肉桂酸,3-硝基-L-苯丙氨酸
参考文献:苯丙氨酸氨解酶和氨基酸变位酶生物催化剂的组合,对芳香族β-氨基酸的动力学拆分
标题:苯丙氨酸氨解酶和氨基酸变位酶生物催化剂的组合,对芳香族β-氨基酸的动力学拆分
摘要:已经证明了使用苯丙氨酸氨基变位酶和氨裂合酶(pam和pal)酶制备(R)-β-芳基丙氨酸的酶促策略.具有海马链霉菌(encp)和芽孢杆菌(bacillus Sp.)选择性(S)选择性的候选pam .(pabh)通过使用充分研究的模板序列进行序列分析来鉴定.新发现的pabh可能与首次提出的幽门螺杆菌样二级代谢产物的生物合成有关,并在许多情况下显示出更好的β-裂合酶活性.尽管如此,Encp的较高的转化率具有严格α-裂解酶合成的方法从多变鱼腥藻(avpal)被认为是更合适的,它允许五种外消旋底物的动力学拆分以及制备规模的对映体过量> 98%(R)的反应.这项工作代表了对现有生物催化策略的一种改进和对映体互补的方法,它允许简单的产品分离和模块化的伸缩组合,以及使用非手性醛作为原料的先前化学步骤.
DOI:10.1002/adsc.201600894

专利信息

专利号:US-2005009151-A1
优先权日:2003-07-10
标 题 :Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
发明人：CHASE MATTHEW; CLAYTON ROBERT; LANDIS BRYAN; BANERJEE AMIT
权利人:PHARMACIA CORP
摘要:The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.

专利号:JP-2007526751-A
优先权日:2003-07-10
标 题:Stereoselective synthesis method and enantiomeric enrichment method of β-amino acid

专利号:WO-2005005633-A2
优先权日:2003-07-10
标 题 :Methods for the stereoselective synthesis and enantiomeric enrichment of b-amino acids

专利号:EP-1646718-A2
优先权日:2003-07-10
标 题 :Methods for the stereoselective synthesis and enantiomeric enrichment of b-amino acids