CAS: 77-48-5; 1,3-Dibromo-5,5-Dimethylimidazolidine-2,4-Dione

上下游产品

1,3-dichloro-5,5-dimethylhydantoin 5,5-dimethyl-imidazolidine-2,4-dione sodium cyanide acetone Bromodiphenylmethane 9H-fluoren-9-yl bromide 4-Bromoveratrole 1-bromo-2-methoxynaphthalene

5,5-二甲基海因置于溴,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 0.58H,以80%的收率获得产物1,3-二溴-5,5-二甲基海因
参考文献:Enantioselective 6-Endo Bromoaminocyclization Of 2,4-Dienyl N-Tosylcarbamates Catalyzed By A Chiral Phosphine Oxide-Sc(Otf)3 Complex. A Dramatic Additive Effect
标题:Enantioselective 6-Endo Bromoaminocyclization Of 2,4-Dienyl N-Tosylcarbamates Catalyzed By A Chiral Phosphine Oxide-Sc(Otf)3 Complex. A Dramatic Additive Effect
摘要:本文描述了由手性膦氧化物-Sc(otf)3复合物催化的有效的对映选择性2,4-二烯基n-对甲苯磺酰氨基甲酸酯的6-内溴氨环化反应,具有显著的添加剂效应.
DOI:10.1039/c5Ob00001G

专利信息

专利号:US-10711138-B2
优先权日:2016-04-08
标题:Intermediates and procedures for the synthesis of functional materials
发明人：KIRSCH PEER; GUNST SUSANN
权利人:MERCK PATENT GMBH
摘要:The present invention relates to heteroaromatic compounds which have two different reactive groups, their use in the synthesis of asymmetrically substituted compounds, and synthesis processes in which the compounds according to the invention are reacted sequentially with two different compounds, whereby an asymmetrically substituted compound is formed.

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:EP-2468735-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-6403793-B2
优先权日:2000-06-12
标 题 :Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：PYE PHILIP J; ROSSEN KAI
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1-[3.5-bis(trifluoromethyl)phenyl]ethenyl]oxy]-3-(4-fluorophenyl)-4-(phenylmethyl) mopholine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6255545-B1
优先权日:1999-06-11
标 题 :Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
发明人：CVETOVICH RAYMOND; TSAY FUH-RONG
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)bromobenzene (CAS 328-70-1). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.