📜1-氰基环丙基甲酸乙酯置于sodium Hydroxide,双氧水体系中,化学反应生成 1-氨基甲酰-1-环丙烷羧酸 参考文献:Stereochemical Studies On The Reactions Catalyzed By The Plp-Dependent Enzyme 1-Aminocyclopropane-1-Carboxylate Deaminase 标题:Stereochemical Studies On The Reactions Catalyzed By The Plp-Dependent Enzyme 1-Aminocyclopropane-1-Carboxylate Deaminase 摘要: DOI:10.1021/ja00330A050
专利号:US-8163773-B2 优先权日:2005-07-11 标题 :Organic compounds 发明人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI 权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG 摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.
专利号:CN-114988999-A 优先权日:2021-11-17 标题 :1-formamido-1-cyclopropane carboxylic acid compound and synthesis method and application of derivative thereof
专利号:US-8013153-B2 优先权日:2006-03-23 标 题:Substituted pyrimidine kinase inhibitors 发明人:BUTLER JEANNENE; CONNOLLY PETER J; FUENTES-PESQUERA ANGEL R; GREENBERGER LEE M; HUANG SHENLIN; LAMONTAGNE JR KENNETH R; LI RONGHUA; XU GUOZHANG 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present invention is directed to substituted pyrimidine compounds of formula (I): n nand forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.
专利号:CN-103864635-B 优先权日:2014-03-27 标题:A simple synthesis process of 1-aminocyclopropane-1-carboxylic acid
专利号:CN-103864635-A 优先权日:2014-03-27 标题:A simple synthesis process of 1-aminocyclopropane-1-carboxylic acid
参考文献:10.1111/j.1747-0285.2009.00924.x 摘要:Liu XH, Chen PQ, Wang BL, Dong WL, Li YH, Xie XQ, Li ZM. High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors. Chem Biol Drug Des. 2010 Feb;75(2):228–32. doi: 10.1111/j.1747-0285.2009.00924.x.