CAS: 6914-74-5; 1-Carbamoylcyclopropanecarboxylic Acid

该化合物是一种有机化合物,其特点是其独特的环丙烷结构,即三环碳环,其特点是一种有机化合物,该化合物的特点是一个碳氨基化合物组(-C(=O)NH2)和一个附于环丙烷环的箱式酸组(-COOH),有助于其反应和在有机合成中的潜在应用.两种功能组的存在都允许各种化学变异,使它成为合成药物和农用化学品的一个多用途中间体.该化合物一般是室内温度固态的,由于存在箱式酸组,可能会在极地溶剂中表现出中等溶性.该化合物的分子结构表明氢结合潜力,这可能影响其物理特性,例如熔点和沸点.此外,该化合物的再活性可归因于环形环中固有的菌株,这可能导致独特的反应途径.

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CAS号6914-79-0 1-氰基-1-环丙烷羧酸 | CAS号6914-71-2 1,1-环丙烷二甲酸二甲酯 | CAS号1559-02-0 1,1-环丙基二羧酸二乙酯 | CAS号57-13-6 尿素 | CAS号1558-81-2 1-氰基环丙烷羧酸乙酯 | CAS号6914-73-4 1-氰基环丙烷羧酸甲酯 | CAS号6914-75-6 1-乙氧基羰基环丙烷-1-尿素 | CAS号141-52-6 乙醇钠 | CAS号68781-13-5 1-氨基环丙烷羧酸盐酸盐 | CAS号22059-21-8 1-氨基环丙烷羧酸 | CAS号5813-85-4 1,1-Cyclopropan...

合成工艺路线路线简述

    📜1-氰基环丙基甲酸乙酯置于sodium Hydroxide,双氧水体系中,化学反应生成 1-氨基甲酰-1-环丙烷羧酸
    参考文献:Stereochemical Studies On The Reactions Catalyzed By The Plp-Dependent Enzyme 1-Aminocyclopropane-1-Carboxylate Deaminase
    标题:Stereochemical Studies On The Reactions Catalyzed By The Plp-Dependent Enzyme 1-Aminocyclopropane-1-Carboxylate Deaminase
    摘要:
    DOI:10.1021/ja00330A050

    海关参考信息

    专利信息


    专利号:US-8163773-B2
    优先权日:2005-07-11
    标题 :Organic compounds
    发明人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI
    权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG
    摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.

    专利号:CN-114988999-A
    优先权日:2021-11-17
    标题 :1-formamido-1-cyclopropane carboxylic acid compound and synthesis method and application of derivative thereof

    专利号:US-8013153-B2
    优先权日:2006-03-23
    标 题:Substituted pyrimidine kinase inhibitors
    发明人:BUTLER JEANNENE; CONNOLLY PETER J; FUENTES-PESQUERA ANGEL R; GREENBERGER LEE M; HUANG SHENLIN; LAMONTAGNE JR KENNETH R; LI RONGHUA; XU GUOZHANG
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:The present invention is directed to substituted pyrimidine compounds of formula (I): n nand forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.

    专利号:CN-103864635-B
    优先权日:2014-03-27
    标题:A simple synthesis process of 1-aminocyclopropane-1-carboxylic acid

    专利号:CN-103864635-A
    优先权日:2014-03-27
    标题:A simple synthesis process of 1-aminocyclopropane-1-carboxylic acid

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1111/j.1747-0285.2009.00924.x
    摘要:Liu XH, Chen PQ, Wang BL, Dong WL, Li YH, Xie XQ, Li ZM. High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors. Chem Biol Drug Des. 2010 Feb;75(2):228–32. doi: 10.1111/j.1747-0285.2009.00924.x.
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