CAS: 5949-16-6; Cinchonine (Sulfate)

该化合物是一种奎宁藻类衍生物,因其立体选择性特性,通常用于手性分辨率和不对称合成. 丙硫酸盐形式提高了水体和极地有机溶剂的溶性,便利了其在催化和分析应用中的使用. 它是一个多功能的手力辅助器,或者在对应选择性反应中,特别是在制药业和精细化学工业中. 化合物的僵硬双环结构有助于其在约束和分离对应物中具有高度选择性. 它在标准条件和精细的再活性下保持稳定,成为需要精确化学控制的研究和工业过程的可靠试剂.

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    专利号:US-2024254636-A1
    优先权日:2023-01-30
    标题 :Chiral magnetic nanocoil and synthesis methods thereof
    发明人:KIM YOUNG KEUN; JEON YOO SANG; JEONG EUNJIN; YOO SUNG JONG; NAM KI TAE; IM SANG WON
    权利人:UNIV KOREA RES & BUS FOUND; KOREA INST SCI & TECH; SEOUL NAT UNIV R&DB FOUNDATION
    摘要:Disclosed herein is a technique for synthesizing chiral magnetic nanocoils using an electrodeposition technique, which can be used to fabricate magnetic nanosensors capable of generating an electric field by strongly reacting to an external magnetic field, such as Faraday's law of electromagnetic induction at the nanoscale, depending on the coil shape of the nanostructure. In accordance with one embodiment, a method of synthesizing a chiral magnetic nanocoil may include generating a primary particle composed of metal ions by applying an external electric field, binding a chiral molecule to a surface of the generated primary particle, and controlling an assembly direction of a next primary particle by the bound chiral molecule.

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    主要参考文献

    [参考文献]: Carol E Griffin, Et Al. Mutation In The Plasmodium Falciparum Crt Protein Determines The Stereospecific Activity Of Antimalarial Cinchona Alkaloids. Antimicrob Agents Chemother. 2012 Oct;56(10):5356-64.
    [参考文献]: Jonas Nyhlén, Et Al. Synthesis And Optical Resolution Of An Allenoic Acid By Diastereomeric Salt Formation Induced By Chiral Alkaloids. Chirality. 2008 Jan;20(1):47-50.
    [参考文献]: Karol M Kacprzak, Et Al. An Improved Synthesis Of 10,11-Didehydro Cinchona Alkaloids. Chirality. 2008 Mar;20(3-4):441-5.
    [参考文献]: Péter Király, Et Al. Self-Association Promoted Conformational Transition Of (3R,4S,8R,9R)-9-[参考文献]: Qing-Min Xu, Et Al. Direct Stm Investigation Of Cinchona Alkaloid Adsorption On Cu(Iii). Langmuir. 2004 Apr 13;20(8):3006-10.

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    摘要:Journal of Pharmacology and Experimental Therapeutics., 78(159), 1943
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