CAS: 56309-56-9; 2-Isopropylphenylisocyanate

相似化合物

56309-60-5 28178-42-9 614-68-6

上下游产品

CAS号851199-82-1 2-isopropylphen... | CAS号917-61-3 氰酸钠 | CAS号75-44-5 光气 | CAS号643-28-7 2-异丙基苯胺 | CAS号88-69-7 2-异丙基苯酚 | CAS号32315-10-9 三光气

📜异丙苯酚置于tris-(Dibenzylideneacetone)Dipalladium(0),2-二叔丁基膦-2',4',6'-三异丙基-3,6-二甲氧基-1,1'-联苯,三(3,6-二氧杂庚基)胺,三乙胺体系中,用 二氯甲烷,甲苯 作为反应溶剂,化学反应 30.0H,反应生成 2-异丙基苯异氰酸酯
参考文献:钯催化合成氨基甲酸芳基酯
标题:钯催化合成氨基甲酸芳基酯
摘要:通过将醇引入钯催化的 Arx (X = Cl,Otf) 与氰酸钠的交叉偶联反应中,实现了芳基氨基甲酸酯的有效合成.在此转化中使用芳基三氟甲磺酸酯作为亲电组分允许扩大用于直接合成芳基异氰酸酯的底物范围.该方法提供了对主要氨基甲酸酯保护基团,S-硫代氨基甲酸酯和聚氨酯材料的二异氰酸酯前体的直接访问.
DOI:10.1021/ol400369N

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2004106598-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting Beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005192269-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005267150-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-6569851-B1
优先权日:1998-06-22
标 题 :Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds