CAS: 479-20-9; 3-Hydroxy-4-(Methoxycarbonyl)-2,5-Dimethylphenyl 3-Formyl-2,4-Dihydroxy-6-Methylbenzoate

该化合物是一种自然形成的化合物,主要在各种地衣物种中发现,被归类为二代代代谢物,它属于被称为脱皮剂的化合物类别,其特征是其独特的结构,包括苯球和箱状酸成分.阿特拉诺林因其黄色至橙色而得到承认,它有助于地衣色色化.该化合物展示了一系列生物活动,包括抗微生物和抗氧化性特性,因此对药理研究感兴趣.此外,阿特拉诺林因其能够抑制某些微生物的生长,因此在化妆品和食品保护方面的潜在应用受到了研究.其有机溶性以及水溶性有限是显著的物理特性,影响着其采掘和在各个领域的应用.总的来说,阿特拉诺林在生态和医学方面都是一种重要的化合物,它突出了自然产品在科学探索中的重要性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号488-87-9 2,5-二甲基间苯二酚 | CAS号479-25-4 赤星衣酸 | CAS号67-56-1 甲醇 | CAS号4707-47-5 2,4-二羟基-3,6-二甲基苯甲酸甲酯 | CAS号39503-14-5 ethyl 3-formyl-... | CAS号34874-90-3 2,4-Dihydroxy-3... | CAS号62392-82-9 2,4-dihydroxy-6... | CAS号34874-78-7 2,4-Dihydroxy-3... | CAS号34883-04-0 3-methoxy-2,4,5...

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    海关参考信息

    专利信息


    专利号:US-8481519-B2
    优先权日:2005-02-05
    标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy
    发明人：HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA
    权利人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA; LOHMANN THERAPIE SYST LTS
    摘要:A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.

    专利号:US-2009143466-A1
    优先权日:2005-02-05
    标题 :Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy

    专利号:CA-2596634-C
    优先权日:2005-02-05
    标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy

    专利号:ZA-200706107-B
    优先权日:2005-02-05
    标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostate hyperplasia, prostate carcinoma, and spinobulbar muscular atrophy

    专利号:WO-2006081997-A2
    优先权日:2005-02-05
    标 题:Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostate hyperplasia, prostate carcinoma, and spinobulbar muscular atrophy

    专利号:DE-102005005399-A1
    优先权日:2005-02-05
    标题 :Isolation of atraric acid, synthesis of atraric acid derivatives and their use of atraric acid and its derivatives for the treatment of benign prostatic hyperplasia and prostate cancer

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    主要参考文献


    1: Shukla I, Azmi L, Gupta SS, Upreti DK, Rao CV. Melioration of anti-hepatotoxic effect by Lichen rangiferinus against alcohol induced liver damage in rats. J Ayurveda Integr Med. 2018 Jan 29. pii: S0975-9476(17)30047-5. doi: 10.1016/j.jaim.2017.08.007. [Epub ahead of print] doi: 10.5941/MYCO.2017.45.4.338. Epub 2017 Dec 31.
    3: Stojanović G, Zlatanović I, Zrnzević I, Stanković M, Stankov Jovanović V, Zlatković B. Hypogymnia tubulosa extracts: chemical profile and biological activities. Nat Prod Res. 2017 Sep
    13:1-5. doi: 10.1080/14786419.2017.1375926. [Epub ahead of print] doi: 10.1007/s11010-017-3178-7. Epub 2017 Sep 8.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1021/np9803777
    摘要:Kumar KC S, Müller K. Lichen Metabolites. 1. Inhibitory Action Against Leukotriene B4Biosynthesis by a Non-Redox Mechanism. J. Nat. Prod. 1999 May 06;62(6):817–20. doi: 10.1021/np9803777.
    参考文献:10.1021/np980378z
    摘要:Kumar KC, Müller K. Lichen metabolites. 2. Antiproliferative and cytotoxic activity of gyrophoric, usnic, and diffractaic acid on human keratinocyte growth. J Nat Prod. 1999 Jun;62(6):821–3. doi: 10.1021/np980378z.
    参考文献:10.1371/journal.pone.0019836
    摘要:Johnson CJ, Bennett JP, Biro SM, Duque-Velasquez JC, Rodriguez CM, Bessen RA, Rocke TE. Degradation of the Disease-Associated Prion Protein by a Serine Protease from Lichens. PLoS ONE. 2011 May 11;6(5):e19836. doi: 10.1371/journal.pone.0019836.
    参考文献:10.1177/1934578x1400900419
    摘要:Stojanović GS, Stanković M, Stojanović IŽ, Palić I, Milovanović V, Rančić S. Clastogenic Effect of Atranorin, Evernic acid, and Usnic Acid on Human Lymphocytes. Natural Product Communications. 2014 Apr;9(4). doi: 10.1177/1934578x1400900419.
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