CAS: 42406-77-9; (S)-2-Amino-3-(4-Hydroxyphenyl)Propionic Acid Benzyl Ester

该化合物是氨酸L-tyrosine的一种受保护衍生物,氨酸L-tyrosine是用苯基醇对碳酸酯组进行酯化的产物,这种改变加强了化合物在有机溶剂中的稳定性和溶性,使其成为聚苯酯合成和制药研究的宝贵中间体.在温度氢解条件下,可以有选择地清除苯基酯组,允许有控制的去保护,而不会影响其他功能组.其晶体形式确保高纯度和易于处理.该化合物在固相聚聚聚苯乙烯(SPS)和制备含有聚苯乙烯的生物活性分子方面特别有用,对反应路径提供精确的控制.

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CAS号5513-40-6 CBZ-L-酪氨酸-Obzl | CAS号19391-35-6 N-(叔丁氧羰基)-L-酪氨酸苄酯 | CAS号22840-03-5 ASP-TYR | CAS号183070-41-9 (S)-BENZYL 2-((... | CAS号968-21-8 L-亮氨酰-L-酪氨酸 | CAS号53587-11-4 L-酪氨酸苄酯对甲苯磺酸盐 | CAS号658-79-7 甘氨酰-L-酪氨酸水合物 | CAS号7432-23-7 Gamma-谷氨酰-酪氨酸 | CAS号75957-53-8 ENALAPRIL | CAS号57294-46-9 L-Tyrosine,N-[N...

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    专利信息


    专利号:US-10442757-B2
    优先权日:2017-06-07
    标 题 :Synthesis of tyrosine derived diphenol monomers
    发明人:PULAPURA SATISH; BUEVICH FATIMA; CHEN XIANGJI; LYU SUPING
    权利人:TYRX INC; MEDTRONIC INC
    摘要:A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.

    专利号:US-5916899-A
    优先权日:1996-10-18
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

    专利号:WO-2018226340-A1
    优先权日:2017-06-07
    标题:Synthesis of tyrosine derived diphenol monomers

    专利号:US-6417195-B1
    优先权日:1999-02-22
    标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAL
    权利人:LION BIOSCIENCE AG
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

    专利号:US-5874443-A
    优先权日:1995-10-19
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

    专利号:CN-110637044-B
    优先权日:2017-06-07
    标 题 :Synthesis of tyrosine-derived polyarylates

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    合成参考文献


    摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 278.
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