CAS: 37758-47-7; Ganglioside Gm1
- 英文名称Ganglioside Gm1
- 中文名称单唾液神经节苷酯
- IUPAC名称sodium (2S,4S,5R,6R)-5-acetamido-2-(((2R,3S,4R,5R,6S)-3-(((2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-(((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3S,4R,5R,6R)-4,5-dihydroxy-6-(((2S,3R,E)-3-hydroxy-2-stearamidooctadec-4-en-1-yl)oxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-5-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylate
- 其它别名Gm1 | Gm1-Ganglioside | Ganglioside A2 | Ganglioside Ggtet1 | Ganglioside Gi | Ganglioside Gm1A | Gm1 . Na
- CAS编号37758-47-7
- MFCD编号:MFCD00466936
- 分子式:C73H134N4O31
- 分子量:1563.85
- 产品CID: 1388170
- 产品分类原料药 → 神经系统用药 → 抗震颤麻痹药
- 相似结构搜索
- 产品信息参考
; - InChIKey: GTTLZSUWCRJZRC-CRQBLQEMSA-N
- GTTLZSUWCRJZRC-CRQBLQEMSA-N…
- 计算化学: 氢键受体数31.0氢键供体数20.0可旋转键数52.0
物理性质
MSDS等安全信息
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海关参考信息
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专利信息
专利号:WO-2024097788-A1
优先权日:2022-11-01
标 题 :Glycosyltransferase engineering for chemoenzymatic total synthesis of gangliosides
发明人：GUCCHAIT ARIN; CHEN XI; YU HAI; ZHANG LIBO
权利人:UNIV CALIFORNIA; GUCCHAIT ARIN
摘要:Described herein are Campylobacter jejuni β1–4GalNAcT (CjCgtA) variants comprising a polypeptide having at least 80% identity to the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2. Also described herein are Campylobacter jejuni β1–3-galactosyltransferase (CjCgtB) variants comprising a polypeptide having at least 80% identity to the amino acid sequence set forth in SEQ ID NO: 3. Optionally, in the CjCgtA and CjCgtB variants, the N-terminus of the polypeptide is fused to a maltose binding protein. Further described herein is a method for preparing a glycosylated molecule, comprising: forming a reaction mixture comprising (i) a glycosylation donor comprising a sugar component; (ii) a glycosylation acceptor comprising a sphingosine moiety; and (iii) a glycosyltransferase, wherein the glycosyltransferase is a CjCgtA variant as described herein or a CjCgtB variant as described herein; and maintaining the reaction mixture under conditions suitable for forming a glycosylated molecule.
专利号:CN-119242659-A
优先权日:2018-06-12
标题:Synthesis of hepadnavirus capsids and uses thereof
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合成参考文献
参考文献:10.1212/wnl.47.4.951
摘要:Taylor BV, Gross L, Windebank AJ. The sensitivity and specificity of anti-GM1 antibody testing. Neurology. 1996 Oct;47(4):951–5. doi: 10.1212/wnl.47.4.951.
参考文献:10.1016/s0165-5728(96)00042-2
摘要:Yuki N, Tagawa Y, Handa S. Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol. 1996 Oct;70(1):1–6. doi: 10.1016/s0165-5728(96)00042-2.
参考文献:10.1046/j.1471-4159.1996.67052134.x
摘要:Sofer A, Futerman AH. Rate of retrograde transport of cholera toxin from the plasma membrane to the Golgi apparatus and endoplasmic reticulum decreases during neuronal development. J Neurochem. 1996 Nov;67(5):2134–40. doi: 10.1046/j.1471-4159.1996.67052134.x.
参考文献:10.1111/j.1348-0421.1996.tb03315.x
摘要:Ishihara S, Okayama A, Nagatomo Y, Murai K, Yamashita R, Okamoto M, Shima T, Sasaki T, Mueller N, Tachibana N, Tsubouchi H. Enhanced engraftment of HTLV-I-infected human T cells in severe combined immunodeficiency mice by anti-asialo GM-1 antibody treatment. Microbiol Immunol. 1996;40(1):39–44. doi: 10.1111/j.1348-0421.1996.tb03315.x.
参考文献:10.1111/j.1348-0421.1996.tb03306.x
摘要:Shida K, Takamizawa K, Takeda T, Osawa T. Characterization by Western Blotting of Mouse Intestinal Glycoproteins Bound by Escherichia coli Heat‐Labile Enterotoxin Type I. Microbiology and Immunology. 1996 Jan;40(1):71–5. doi: 10.1111/j.1348-0421.1996.tb03306.x.
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