CAS: 31930-34-4; Ethyl Cis-3-Bromoacrylate

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6213-89-4 37746-78-4 31930-37-7

上下游产品

2-Brom-1-(diphenylboryl)-1-ethencarbonsaeure-ethylester propynoic acid ethyl ester ethyl (Z)-3-iodopropenoate 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-acrylic acid ethyl esterethyl 6-phenylhex-5-yn-(2Z)-enoate cis-3-bromo-2-propen-1-ol Diethyl trans-hex-3-enedioate cis-3-Hexendicarbonsaeurediaethylester

📜顺式-3-碘丙烯酸乙酯置于copper(L) Iodide,四甲基溴化铵,(1R,2R)-(-)-N,N'-二甲基-1,2-环己二胺体系中,用 乙醇 用作溶剂,化学反应 72.0H,以55%的收率获得顺-3-溴丙烯酸乙酯
参考文献:通用的铜催化乙烯基芬克尔斯坦反应的发展-用于合成laingolide B的c1-C9片段
标题:通用的铜催化乙烯基芬克尔斯坦反应的发展-用于合成laingolide B的c1-C9片段
摘要:据报道,铜催化的乙烯基芬克尔斯坦反应的一种有效且广泛适用的方法.使用简单,易于获得且便宜的催化系统,可以将各种烯基碘化物和溴化物平稳地转化为它们的较低同系物,并具有高收率并完全保留双键的几何形状.这种乙烯基finkelstein反应的关键特征是其广泛的适用性,使易得的链烯基碘化物转化为难得的溴代和氯代对应物,并且温和的反应条件与一系列高度官能化的底物相容.这种乙烯基卤素交换反应在全合成和药物化学中的潜力已通过成功地用于合成laingolide B的c1-C9片段以及对药物样分子进行后期修饰而得到证明.还报道了这种卤素交换扩展到炔属和烯属的finkelstein反应.
Doi:10.1016/j.Tet.2016.07.018

专利信息

专利号:US-9102650-B2
优先权日:2014-08-08
标 题:Synthesis of new anti-inflammatory compound
发明人：XU YONG
权利人:XU YONG
摘要:According to embodiments of present disclosure, a method to produce a compound of Formula 19 is provided. Using this method, the compound of Formula 19 may be produced effectively.

专利号:US-7405310-B2
优先权日:2001-03-05
标 题:Non-nucleoside reverse transcriptase inhibitors
发明人：LINDSTROM STEFAN; SAHLBERG CHRISTER; WALLBERG HANS; KALYANOV GENAIDY; ODEN LOURDES SALVADOR; NAESLUND LOTTA
权利人:MEDIVIR AB
摘要:This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

专利号:US-2015112087-A1
优先权日:2014-08-08
标 题 :Synthesis of New Anti-Inflammatory Compound

专利号:WO-2016019907-A1
优先权日:2014-08-08
标 题 :Synthesis of new anti-inflammatory compound