CAS: 252054-88-9; 1-(Trimethylsilyl)-2-Naphthyl Trifluoromethanesulfonate

该化合物是一种用于合成有机化学,特别是用于光电芳香替代和交叉组合反应的专门的有机硅试剂,其主要优点包括:由于电离式三氟乙烷磺酸酯组,可促进芳香系统高效功能化,从而增强反应性;三甲基硅酸盐混合物提供了...

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780820-43-1 3857-83-8 151391-00-3

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上下游产品

CAS号358-23-6 三氟甲磺酸酐 | CAS号573-97-7 1-溴-2-萘酚 | CAS号999-97-3 六甲基二硅氮烷 | CAS号321-38-0 1-氟萘 | CAS号403646-52-6 1-(trifluoromet... | CAS号27715-42-0 1,2-二碘萘 | CAS号574-96-9 1-羟基-2-萘甲醛 | CAS号708-06-5 2-羟基-1-萘甲醛 | CAS号1096920-53-4 (4-bromophenyl)... | CAS号760192-88-9 4-BROMOPHENYL-2... | CAS号479-79-8 11H-苯并[a]芴-11-酮

合成工艺路线路线简述

    📜1-溴-2-萘酚置于正丁基锂体系中,用 四氢呋喃 用作溶剂,化学反应 4.5H,反应生成三氟甲磺酸1-(三甲基硅基)-2-萘酯
    参考文献:三氟甲基芳基磺酸盐(tfms):适用的三氟甲氧基化试剂
    标题:三氟甲基芳基磺酸盐(tfms):适用的三氟甲氧基化试剂
    摘要:氮之后,氟可能是掺入小分子中的另一个最受欢迎的杂原子.在许多含氟基团中,三氟甲基芳基醚(arocf 3)在药物设计中具有独特的特性,难以合成,因此开发了许多不同的方法来制备它们.的一种新的一锅法合成ø-碘-芳基三氟甲基醚(arocf 3 I)用的反应描述trifluoromethoxylation和碘化与三氟甲基芳基磺酸盐(tfms)在该手稿.通过筛选不同的溶剂,冠醚,底物来优化反应条件,并且产物的比例和收率处于中等至高收率(高达86%).
    Doi:10.1016/j.Tetlet.2019.04.033

    海关参考信息

    专利信息


    专利号:US-2021323987-A1
    优先权日:2018-08-20
    标题:Methods for the Synthesis of Heteroatom Containing Polycyclic Aromatic Hydrocarbons
    发明人：GARG NEIL K; DARZI EVAN R; BARBER JOYANN S; SUSICK ROBERT; CHARI JASON; SPENCE KATIE
    权利人:UNIV CALIFORNIA
    摘要:Methods for the synthesis of polycyclic aromatic hydrocarbons and synthesis platforms for performing such syntheses are provided. Methods and platforms are provided that allow for the synthesis of aza-polycyclic aromatic hydrocarbons by an expedient ring assembly. Methods and platforms allow for a modular approach to synthesis that provide multiple new C—C bonds in sequential pericyclic reactions, thus giving access to compounds with multiple axes of substitution.

    专利号:WO-2020041369-A1
    优先权日:2018-08-20
    标 题:Methods for the synthesis of heteroatom containing polycyclic aromatic hydrocarbons

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Thiophenols As Protic Nucleophilic Triggers In Aryne Three-Component Coupling
    作者:Subrata Bhattacharjee,Avishek Guin,Rahul N. Gaykar,Akkattu T. Biju |发布日期:2020.11.20
    摘要:The Synthetic Potential Of Thiophenols As A Protic Nucleophilic Trigger In The Transition-Metal-Free And Grignard-Reagent-Free Three-Component Coupling Involving Arynes Is Demonstrated. Employing Aldehydes As The Third Component, The Reaction Allowed The Mild And Broad Scope Synthesis Of 2-Arylthio Benzyl Alcohol Derivatives In Good Yields. Moreover, Selenophenol Could Be Used As The Nucleophilic Trigger

    合成参考文献


    摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 66.
    摘要:Menon, R. S.; Nair, V., Science of Synthesis: Multicomponent Reactions, (2013) 1, 510.
    摘要:Yoshikai, N., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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