CAS: 23364-44-5; (1S,2R)-2-Amino-1,2-Diphenylethanol

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CAS号441-38-3 α-安息香肟 | CAS号620141-05-1 (1R,2S)-1,2-dip... | CAS号350479-90-2 (SS)-(+)-N-(ben... | CAS号302934-11-8 (S)-2-(Triisopr... | CAS号620140-01-4 [1R,2S,(S)S]-N-... | CAS号530-36-9 1,2-二苯基-2-氨基乙醇 | CAS号620141-00-6 (1R,2S)-1-pheny... | CAS号620140-92-3 [1R,2S,(S)S]-N-... | CAS号86286-50-2 (4R,5S)-4,5-二苯基... | CAS号105228-46-4 (2S,3R)-N-苄氧羰基-... | CAS号112741-50-1 (2S,3R)-N-叔丁氧羰基... | CAS号142508-07-4 (1S,2r)-2-(异丙基氨... | CAS号112835-62-8 2-((1R,2S)-2-羟基...

(S)-2-(Triisopropylsyloxymethyl)Phenyl P-Tolylsulfoxide置于镍 Cesium Fluoride,三氟乙酸,Lithium Diisopropyl Amide体系中,用 四氢呋喃,甲醇,正己烷 用作溶剂,化学反应 4.0H,反应生成(1S,2R)-2-氨基-1,2-二苯基乙醇
参考文献:Stereocontrolled Reactions Mediated By A Remote Sulfoxide Group: Synthesis Of Optically Pure Anti-β-Amino Alcohols
标题:Stereocontrolled Reactions Mediated By A Remote Sulfoxide Group: Synthesis Of Optically Pure Anti-β-Amino Alcohols
摘要:A One-Step Synthesis Of Enantiomerically Pure Anti-1,2-Amino Alcohol Derivatives Has Been Achieved By Reaction Of Prochiral Oxygenated 2-P-Tolylsulfinylbenzyl Carbanions With N-Sulfinylimines Bearing The Same Configuration At Sulfur.
Doi:10.1021/ol0358410

专利信息

专利号:US-2024400517-A1
优先权日:2022-02-08
标 题 :Chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline
发明人：ZHANG WANBIN; GAO FENG; LI JING; AHMAD TANVEER; ZHANG ZHENFENG; YUAN QIANJIA
权利人:UNIV SHANGHAI JIAOTONG
摘要:A chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, the chiral bimetallic cooperative catalysis system is formed by a metallic lithium, sodium or potassium salt and another metal salt under the action of a suitable ligand and an additive. By means of the chiral bimetallic cooperative catalysis system, an addition reaction of 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) is promoted, the selectivity is regulated, and a target product, (1R,2S)-bedaquiline, with high yield and high selectivity is obtained for the first time.

专利号:US-7723539-B2
优先权日:2004-06-16
标题:Catalysts based on metal complexes for the synthesis of optically active chrysanthemic acid
发明人：CARLONI SILVIA; BORZATTA VALERIO; MORONI LENI; TANZI GIADA; SARTORI GIOVANNI; MAGGI RAIMONDO
权利人:ENDURA SPA
摘要:Catalysts are described based on metal complexes derived from optically active s compounds, chosen from the classes consisting of bisoxazolines and salicylaldimines supported on an organic or inorganic matrix and employed in particular for the synthesis of optically active chrysanthemic acid.

专利号:WO-2025104679-A1
优先权日:2023-11-16
标题 :Processes for making intermediates for isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity
发明人：SHAKYA SAGAR; JOHNSON MATT; WONG NICHOLAS; BODHURI PRABHUDAS; DAVAR NIPUN
权利人:OTSUKA PHARMA CO LTD
摘要:The present disclosure relates to processes for preparing synthetic intermediates for the synthesis of isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity.

专利号:US-12077801-B2
优先权日:2017-04-07
标 题:Regioselective hydroxylation of isophorone
发明人：BONRATH WERNER; SCHÃœRMANN MARTIN; TAVANTI MICHELE; PARMEGGIANI FABIO; TURNER NICHOLAS; MATTEVI ANDREA; CASSTELLANOS JOSE RUBEN
权利人:DSM IP ASSETS BV
摘要:The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of α-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.

专利号:US-12378246-B2
优先权日:2019-04-11
标 题:Synthetic options towards the manufacture of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl} - 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one
发明人：CUNIERE NICOLAS; FAN YU; KOLOTUCHIN SERGEI; MUKHERJEE SUBHA; SIMMONS ERIC M; SINGH AMARJIT; WEI CAROLYN S; XIAO YI; YUAN CHANGXIA; ZHENG BIN; WAGSCHAL SIMON ALBERT; BROGGINI DIEGO FERNANDO DOMENICO; CAO DUY CHI TRUNG; CHERNICHENKO KOSTIANTYN; LEMAIRE SEBASTIEN FRANCOIS EMMANUEL; BEN HAÃ?M CYRIL
权利人:BRISTOL MYERS SQUIBB CO; JANSSEN PHARMACEUTICA NV
摘要:Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

专利号:US-2022048879-A1
优先权日:2020-08-13
标 题:Synthesis of small molecules inspired by Phomoxanthone A
发明人：ALI RAMEEZ; MATTSON ANITA
权利人:WORCESTER POLYTECH INST
摘要:Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.