CAS: 21149-38-2; 2,2,2-Trifluoro-N,N-Bis(Trimethylsilyl)Acetamide

该化合物是一种化学化合物,通常用作分析化学,特别是气相色谱和质谱测量的衍生剂,具有三氟乙酰三氟乙酰功能组,它能增加极化合物的挥发性和热稳定性,使其更易于分析.两个三甲基环乙酰胺组的存在增加了分子的疏水性,有利于酒精,氨和盒状酸的衍生.这种化合物一般是色素无色的,具有特异味的淡黄色液体,在标准条件下相对稳定,但应谨慎处理,因为它具有湿度,可导致三氟乙酰胺释放.N,N-Bis(三甲基硅)三氟乙酰乙酰胺在有机溶剂中是可溶的,并经常与其他试剂一起用于改进各种分析应用中的检测限度和复杂混合物的分辨率.在处理这一化合物时,应注意适当的安全防范措施,因为它可能构成接触化合物的健康风险.

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合成工艺路线路线简述

    📜六甲基二硅氮烷,三甲基氯硅烷 反应生成2,2,2-三氟-N,N-二(三甲硅基)乙酰胺
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    专利信息


    专利号:EP-1309698-B1
    优先权日:2000-07-21
    标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants
    发明人:CAHOON EDGAR B
    权利人:DU PONT
    摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.

    专利号:EP-0946571-B1
    优先权日:1996-12-12
    标 题:Synthesis of bis trialkylsilylamide and resulting composition
    发明人:FORAT GERARD
    权利人:RHODIA CHIMIE SA
    摘要:The invention concerns the synthesis of bis trialkylsilylamide which consists in: subjecting the amide to the action of a trialkylsilyl halide on an amide bearing a Rf group in the presence of a base whose halide, or halohydrate is insoluble in the medium and in the presence of a covalent and non-hydrophilic solvent. The invention is applicable to organic synthesis.

    专利号:US-2023287032-A1
    优先权日:2020-08-14
    标 题:Synthesis of fluorinated nucleotides
    发明人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO
    权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC
    摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

    专利号:US-6143887-A
    优先权日:1998-05-14
    标题:Process for the stereoselective synthesis of 16-substituted-4-aza-androstanones
    发明人:GRATALE DOMINICK F; TOLMAN RICHARD L; SAHOO SOUMYA P
    权利人:MERCK & CO INC
    摘要:The novel process of the present invention involves the stereoselective synthesis of certain 16β-substituted 4-aza-5α-androstan-3-ones and the useful intermediates obtained therein.

    专利号:US-4739043-A
    优先权日:1984-07-19
    标题 :Method for the synthesis of alkyl, cycloalkyl or alcenyl aldosides or polyaldosides
    发明人:DEFAYE JACQUES; WONG EMILE; PEDERSEN CHRISTIAN; CHEDIN JEAN; BOUCHU ALAIN
    权利人:BEGHIN SAY SA
    摘要:PCT No. PCT/FR85/00197 Sec. 371 Date Apr. 18, 1986 Sec. 102(e) Date Apr. 18, 1986 PCT Filed Jul. 18, 1985 PCT Pub. No. WO86/00906 PCT Pub. Date Feb. 13, 1986.The process comprises the action of a saturated aliphatic or cycloaliphatic alcohol or an aliphatic or cycloaliphatic alcohol comprising a double ethylenic bound not situated in alpha of the hydroxyl group with an aldose, aldoside or polyaldoside in the solvent and reactant formed by the hydrogen fluoride. Application to the synthesis of surfactants or as additives for rigidifying polyurethane foams.

    专利号:US-5326885-A
    优先权日:1992-05-01
    标 题 :Process of preparing enriched enantiomers of glycerol carbonate and derivatives thereof for synthesis of β-blockers
    发明人:OLIVERO ALAN G; CASSEL JONATHAN M; POULSEN JAMES R
    权利人:COGNIS INC
    摘要:Enriched enantiomers of glycerol Carbonate are produced under the influence of a hydrolytic enzyme, either by selective esterification of racemic glycerol carbonate or by selective hydrolysis of an ester of the racemate. The enriched enantiomeric product is readily converted to starting materials and intermediates useful in the synthesis of enantiomerically pure therapeutic agents, such as beta -adrenergic blockers.

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    合成参考文献


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    参考文献:10.1007/s00299-011-1119-6
    摘要:Burlini N, Iriti M, Daghetti A, Faoro F, Ruggiero A, Bernasconi S. Benzothiadiazole (BTH) activates sterol pathway and affects vitamin D3 metabolism in Solanum malacoxylon cell cultures. Plant Cell Rep. 2011 Nov;30(11):2131–41. doi: 10.1007/s00299-011-1119-6.
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