专利号:EP-1309698-B1 优先权日:2000-07-21 标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants 发明人:CAHOON EDGAR B 权利人:DU PONT 摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.
专利号:EP-0946571-B1 优先权日:1996-12-12 标 题:Synthesis of bis trialkylsilylamide and resulting composition 发明人:FORAT GERARD 权利人:RHODIA CHIMIE SA 摘要:The invention concerns the synthesis of bis trialkylsilylamide which consists in: subjecting the amide to the action of a trialkylsilyl halide on an amide bearing a Rf group in the presence of a base whose halide, or halohydrate is insoluble in the medium and in the presence of a covalent and non-hydrophilic solvent. The invention is applicable to organic synthesis.
专利号:US-2023287032-A1 优先权日:2020-08-14 标 题:Synthesis of fluorinated nucleotides 发明人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO 权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC 摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
专利号:US-6143887-A 优先权日:1998-05-14 标题:Process for the stereoselective synthesis of 16-substituted-4-aza-androstanones 发明人:GRATALE DOMINICK F; TOLMAN RICHARD L; SAHOO SOUMYA P 权利人:MERCK & CO INC 摘要:The novel process of the present invention involves the stereoselective synthesis of certain 16β-substituted 4-aza-5α-androstan-3-ones and the useful intermediates obtained therein.
专利号:US-4739043-A 优先权日:1984-07-19 标题 :Method for the synthesis of alkyl, cycloalkyl or alcenyl aldosides or polyaldosides 发明人:DEFAYE JACQUES; WONG EMILE; PEDERSEN CHRISTIAN; CHEDIN JEAN; BOUCHU ALAIN 权利人:BEGHIN SAY SA 摘要:PCT No. PCT/FR85/00197 Sec. 371 Date Apr. 18, 1986 Sec. 102(e) Date Apr. 18, 1986 PCT Filed Jul. 18, 1985 PCT Pub. No. WO86/00906 PCT Pub. Date Feb. 13, 1986.The process comprises the action of a saturated aliphatic or cycloaliphatic alcohol or an aliphatic or cycloaliphatic alcohol comprising a double ethylenic bound not situated in alpha of the hydroxyl group with an aldose, aldoside or polyaldoside in the solvent and reactant formed by the hydrogen fluoride. Application to the synthesis of surfactants or as additives for rigidifying polyurethane foams.
专利号:US-5326885-A 优先权日:1992-05-01 标 题 :Process of preparing enriched enantiomers of glycerol carbonate and derivatives thereof for synthesis of β-blockers 发明人:OLIVERO ALAN G; CASSEL JONATHAN M; POULSEN JAMES R 权利人:COGNIS INC 摘要:Enriched enantiomers of glycerol Carbonate are produced under the influence of a hydrolytic enzyme, either by selective esterification of racemic glycerol carbonate or by selective hydrolysis of an ester of the racemate. The enriched enantiomeric product is readily converted to starting materials and intermediates useful in the synthesis of enantiomerically pure therapeutic agents, such as beta -adrenergic blockers.
参考文献:10.1007/s10886-010-9749-7 摘要:Tharayil N, Triebwasser DJ. Elucidation of a Diurnal Pattern of Catechin Exudation by Centaurea stoebe. Journal of Chemical Ecology. 2010 Feb 16;36(2):200–4. doi: 10.1007/s10886-010-9749-7. 参考文献:10.1007/978-1-61779-188-8_2 摘要:Gaynor JW, Cosstick R. Dinucleotides containing 3'-S-phosphorothiolate linkages. Methods Mol Biol. 2011;764():17–30. doi: 10.1007/978-1-61779-188-8_2. 参考文献:10.1007/s00253-005-0203-7 摘要:Otsuka Y, Nakamura M, Shigehara K, Sugimura K, Masai E, Ohara S, Katayama Y. Efficient production of 2-pyrone 4,6-dicarboxylic acid as a novel polymer-based material from protocatechuate by microbial function. Applied Microbiology and Biotechnology. 2005 Dec 02;71(5):608–14. doi: 10.1007/s00253-005-0203-7. 参考文献:10.1007/s00299-011-1119-6 摘要:Burlini N, Iriti M, Daghetti A, Faoro F, Ruggiero A, Bernasconi S. Benzothiadiazole (BTH) activates sterol pathway and affects vitamin D3 metabolism in Solanum malacoxylon cell cultures. Plant Cell Rep. 2011 Nov;30(11):2131–41. doi: 10.1007/s00299-011-1119-6.