3,3'-二氯二苯二硫醚置于三苯基膦体系中,用 1,4-二氧六环,水 用作溶剂,化学反应生成3-氯苯硫酚 参考文献:Nucleophilic Cleavage Of The Sulfur-Sulfur Bond By Phosphorus Nucleophiles. Kinetic Study Of The Reduction Of Aryl Disulfides With Triphenylphosphine And Water 标题:Nucleophilic Cleavage Of The Sulfur-Sulfur Bond By Phosphorus Nucleophiles. Kinetic Study Of The Reduction Of Aryl Disulfides With Triphenylphosphine And Water 摘要: Doi:10.1021/ja00826A021
专利号:US-2016318862-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds 发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
专利号:EP-3049072-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds
专利号:US-4358606-A 优先权日:1981-06-19 标 题:Esters of phenalkyloxycarbonylamino acids 发明人:LEE SHY-FUH; HENRICK CLIVE A 权利人:ZOECON CORP 摘要:Novel esters of phenylalkyloxy- or phenylalkylthioacylamino acids and pyridylalkyloxy- or pyridylalkylthioacylamino acids, synthesis thereof, intermediates therefor, and the use of said esters for the control of weeds.
专利号:US-6403814-B1 优先权日:1998-10-16 标 题 :Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans 发明人:RAO ALLA VENKATA RAMA; CHORGHADE MUKUND S; ISLAM AMIN UL; RAO VEMURI VENKATA KIRAN; PRASAD ANEGONDI SREENIVASA; RAO BATCHU VENKATESWARA; REDDY RANGA; REDDY LALATA KRISHNAKANTH; SHAILAJA KOTAKONDA; GURJAR MUKUND KESHAO; MHASKAR SUNIL VYANKATESH 权利人:MILLENNIUM PHARM INC 摘要:A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N'-methyl-N'-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.
专利号:CN-106905361-A 优先权日:2017-01-26 标题:A kind of synthetic method of phosphorothioate compound and the application of this method in the synthesis of various medicines
专利号:WO-2015048268-A1 优先权日:2013-09-25 标题 :Synthesis of delta 12-pgj3 and related compounds
摘要:Schatz, J.; Seßler, M., Science of Synthesis Knowledge Updates, (2010) 1, 95. 摘要:Kosarev, S. A., Science of Synthesis Knowledge Updates, (2012) 2, 240. 摘要:Tsubouchi, A., Science of Synthesis Knowledge Updates, (2016) 2, 344. 摘要:Ayad, T.; Pirat, J.-L.; Virieux, D., Science of Synthesis Knowledge Updates, (2022) 1, 321. 摘要:P. DeMaria, A. Fini and F. M. Hall, J. Chem. Soc., Perkin Trans. 2 1973, 1969.