CAS: 2037-31-2; 3-Chlorobenzenethiol

该化合物是有机硫化合物,其特点是存在硫醇(-SH)组和一个附于硫苯环的氯原子.该化合物一般是无色的,可粉黄液体,有独特的气味.它溶于有机溶剂,但因其含氢恐惧的硫苯结构,在水中溶解性有限.在三处放置硫酚环时,氯的替代成分会影响其再活动,使其成为有机合成中的有用中间体,特别是在生产药品,农用化学品和其他精密化学品方面.3-Choloothiophenol可经受各种化学反应,包括核糖代用品和电荷芳香替代物,因为氯原子具有电镀性质.在处理该化合物时,必须采取安全防范措施,因为通过皮肤吸入或吸收,可能会造成伤害,而且可能对环境造成危害.应采用适当的储存和处置方法,以减少其风险.

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CAS号108-42-9 间氯苯胺 | CAS号2402-00-8 (3-chlorophenyl... | CAS号19742-92-8 3,3'-二氯二苯二硫醚 | CAS号55975-72-9 Ethyl-3-chlorph... | CAS号3996-38-1 2-(3-chlorophen... | CAS号848189-72-0 dithi°Carbonic ... | CAS号104-86-9 4-氯苄胺 | CAS号287471-39-0 m-chlorophenyl ... | CAS号2393-23-9 对甲氧基苄胺 | CAS号100-46-9 苄胺 | CAS号4867-37-2 3-氯茴香硫醚 | CAS号22731-83-5 S,S-联苯砜基亚胺 | CAS号51-28-5 2,4-二硝基酚 | CAS号19742-92-8 3,3'-二氯二苯二硫醚 | CAS号2888-06-4 3-氯苯磺酰氯 | CAS号13735-14-3 7-Chloro-2,3-di... | CAS号13420-58-1 2-(3-chlorophen... | CAS号1132-52-1 3-(3-chlorophen... | CAS号125056-61-3 6-(3-chlorophen...

合成工艺路线路线简述

    3,3'-二氯二苯二硫醚置于三苯基膦体系中,用 1,4-二氧六环,水 用作溶剂,化学反应生成3-氯苯硫酚
    参考文献:Nucleophilic Cleavage Of The Sulfur-Sulfur Bond By Phosphorus Nucleophiles. Kinetic Study Of The Reduction Of Aryl Disulfides With Triphenylphosphine And Water
    标题:Nucleophilic Cleavage Of The Sulfur-Sulfur Bond By Phosphorus Nucleophiles. Kinetic Study Of The Reduction Of Aryl Disulfides With Triphenylphosphine And Water
    摘要:
    Doi:10.1021/ja00826A021

    海关参考信息

    专利信息


    专利号:US-2016318862-A1
    优先权日:2013-09-25
    标 题:Synthesis of delta 12-pgj3 and related compounds
    发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
    权利人:UNIV RICE WILLIAM M
    摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

    专利号:EP-3049072-A1
    优先权日:2013-09-25
    标 题:Synthesis of delta 12-pgj3 and related compounds

    专利号:US-4358606-A
    优先权日:1981-06-19
    标 题:Esters of phenalkyloxycarbonylamino acids
    发明人:LEE SHY-FUH; HENRICK CLIVE A
    权利人:ZOECON CORP
    摘要:Novel esters of phenylalkyloxy- or phenylalkylthioacylamino acids and pyridylalkyloxy- or pyridylalkylthioacylamino acids, synthesis thereof, intermediates therefor, and the use of said esters for the control of weeds.

    专利号:US-6403814-B1
    优先权日:1998-10-16
    标 题 :Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
    发明人:RAO ALLA VENKATA RAMA; CHORGHADE MUKUND S; ISLAM AMIN UL; RAO VEMURI VENKATA KIRAN; PRASAD ANEGONDI SREENIVASA; RAO BATCHU VENKATESWARA; REDDY RANGA; REDDY LALATA KRISHNAKANTH; SHAILAJA KOTAKONDA; GURJAR MUKUND KESHAO; MHASKAR SUNIL VYANKATESH
    权利人:MILLENNIUM PHARM INC
    摘要:A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N'-methyl-N'-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.

    专利号:CN-106905361-A
    优先权日:2017-01-26
    标题:A kind of synthetic method of phosphorothioate compound and the application of this method in the synthesis of various medicines

    专利号:WO-2015048268-A1
    优先权日:2013-09-25
    标题 :Synthesis of delta 12-pgj3 and related compounds
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    合成参考文献


    摘要:Schatz, J.; Seßler, M., Science of Synthesis Knowledge Updates, (2010) 1, 95.
    摘要:Kosarev, S. A., Science of Synthesis Knowledge Updates, (2012) 2, 240.
    摘要:Tsubouchi, A., Science of Synthesis Knowledge Updates, (2016) 2, 344.
    摘要:Ayad, T.; Pirat, J.-L.; Virieux, D., Science of Synthesis Knowledge Updates, (2022) 1, 321.
    摘要:P. DeMaria, A. Fini and F. M. Hall, J. Chem. Soc., Perkin Trans. 2 1973, 1969.
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