CAS: 1836-62-0; 2-(2-Methoxyphenoxy)Ethylamine

上下游产品

CAS号26646-63-9 2-[2-(2-Methoxy... | CAS号183427-87-4 2-(2-甲氧基苯氧基)乙酰胺 | CAS号53815-60-4 愈创木酚 2-氯乙基醚 | CAS号90-05-1 愈创木酚 | CAS号4463-59-6 2-(2-甲氧基苯氧基)溴乙烷 | CAS号918903-20-5 卡维地洛杂质B | CAS号72956-09-3 卡维地洛 | CAS号787598-91-8 (+/-)-1-(9H-car... | CAS号72955-94-3 N-苄基卡维地洛 | CAS号3246-03-5 N-(2-(2-甲氧基苯氧基)... | CAS号1198090-73-1 卡维地洛杂质1 | CAS号72956-44-6 O-去甲卡维地洛

木榴油置于18-冠醚-6,Potassium Carbonate,一水合肼体系中,用 甲醇,N,N-二甲基甲酰胺,丙酮 用作溶剂,化学反应 18.0H,反应生成2-甲氧基苯氧基乙胺
参考文献:更环保,更快速地合成基于苯甲酰的席夫碱配体作为高效抗菌剂,抗氧化剂和抗癌剂
标题:更环保,更快速地合成基于苯甲酰的席夫碱配体作为高效抗菌剂,抗氧化剂和抗癌剂
摘要:摘要 使用生态友好的超声处理方案,通过将苯甲醛及其对位衍生物与 2-(2-甲氧基苯氧基) 乙胺结合,生产了某些基于苯甲醛的席夫碱配体.反应持续约 2 分钟,产生 86.27% 的席夫碱配体.人类肿瘤细胞系用于测试配体抗癌作用,结果显示 Mpea-Ani(抗乳腺癌 Mda Mb 231 为 71%,肺癌 A 549 为 85%)对两种细胞系均表现出显着抑制作用.通过配体对 Dpph,过氧化氢和一氧化氮自由基的清除作用,研究了配体的抗氧化性能.用于评估配体抗菌效果的细菌菌株是枯草芽孢杆菌,金黄色葡萄球菌(革兰氏阳性菌)和大肠杆菌(革兰氏阴性菌).使用元素分析,Ft-Ir,1 H NMR,13 C NMR 和质谱描述配体.
Doi:10.1080/00397911.2023.2172349

专利信息

专利号:US-2007197797-A1
优先权日:2005-12-30
标 题 :Compounds and methods for carbazole synthesis
发明人：HARRINGTON PETER J
权利人:HARRINGTON PETER J
摘要:Compounds having bi-cyclic structure comprising a partially unsaturated 6-carbon first cyclic moiety interconnected to a 6-carbon second cyclic moiety second via a divalent linking moiety are provided. The compounds can be used as intermediates compounds in methods for the synthesis of carbazoles and derviatives thereof, including carvedilol, and tricyclic alkylhydroxamates, which do not require Fischer indole synthetic steps. Methods of preparing the compounds having bi-cyclic structures are also provided.

专利号:US-7534895-B2
优先权日:2002-11-08
标 题:Process for preparation of carvedilol
发明人：HERCEK RICHARD; SKODA ALOJZ; PROKSA BOHUMIL
权利人:ZENTIVA AS
摘要:The invention solves a new method of preparation of Carvedilol for pharmaceutical use. In the synthesis of Carvedilol a reaction of 4-(oxirane-2-ylmethoxy)-9H-arbazole (II) with 2-(2-methoxyphenoxy)ethylamine salts (IV) in the presence of a base, in an alcohol having the number of carbons C2 to C5 as a solvent, at an elevated temperature, is used. After processing of the crude reaction mixture crude Carvedilol is obtained, which is purified by crystallization from ethylacetate with an addition of activated carbon and the final substance is formulated by crystallization from ethylacetate.

专利号:WO-2009157015-A8
优先权日:2008-06-04
标 题 :Synthesis of 1-(carbazol-4-yloxy)-3-[[2-(o- methoxyphenoxy)ethyl]amino]-2-propanol
发明人：RAY PURNA CHANDRA; LAKONDA NAGAPRASADA RAO; SATYENDER APURI; REDDY R BUCHI
权利人:INOGENT LAB PRIVATE LTD; RAY PURNA CHANDRA; LAKONDA NAGAPRASADA RAO; SATYENDER APURI; REDDY R BUCHI
摘要:The present invention relates to an improved process for the preparation of Carvedilol, wherein, the process involves the use of organic base in the reaction of 4-(oxirane-2ylmethoxy)-9H-carbazole with 2-(2-methoxyphenoxy) ethylamine in presence of a solvent. While preparing Carvedilol minimum amount of bis-impurity was obtained without purification.

专利号:WO-03095416-A1
优先权日:2002-05-07
标 题 :Method for preparing 2-alkoxyphenoxyethanamines from 2-alkoxyphenoxyethylacetamides
发明人：MATERNE CARSTEN; KHAN IMAN
权利人:MCM PHARMA GMBH; NAKODA CHEMICALS LTD; MATERNE CARSTEN; KHAN IMAN
摘要:The present invention relates to a method for preparing 2-Alkoxyphenoxyethanamines and more particularly relates to the preparation of the new chemical entity 2-Alkoxyphenoxyethylacetamides, in particular as intermediates in said method. An industrial process for the synthesis of 2-Alkoxyphenoxyethanamines which is cheap and easy to perform, is a long felt need for those skilled in the art. The object of the present invention is therefore to provide a process for the industrial production of phenoxyethanamine which is cheap and easy to perform. This object is solved by the new chemical entity 2-Alkoxyphenoxyacetamide which is prepared by reacting an ortho substituted phenol with a 2-Alkyloxazoline. By hydrolysis of the acetamide with water in the presence of organic or mineral acids such as hydrochloric acid and/or sulfuric acid, the 2-Alkylphenoxyethanamine is obtained.

专利号:EP-1375474-B1
优先权日:2000-05-18
标 题 :Intermediate for the preparation of carvedilol
发明人：PITTELKOW THOMAS; FISCHER ERIK; TREPPENDAHL SVEND PETER
权利人:GEA FARMACEUTISK FABRIK AS
摘要:A new intermediate having the formula (VI) wherein X and Y are leaving groups; is disclosed. The new intermediate is useful for the preparation of carvedilol in a synthesis that avoids the use of any oxirane or similar hazardous reacgents.

专利号:WO-2009157015-A3
优先权日:2008-06-04
标题:Synthesis of l-(carbazol-4-yloxy)-3-[[2-(o- methoxyphenoxy)ethyl]amino]-2-propanol