CAS: 17466-45-4; Phalloidin

📜维生素 C置于碘,三氟乙酸体系中,用 水,4-(Dicyanomethylene)-2-Methyl-6-(P-Dimethylaminostyryl)-4H-Pyran,乙酸乙酯,N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应生成毒伞素
参考文献:Preparation Of Phalloidin And Its Derivatives
标题:Preparation Of Phalloidin And Its Derivatives
摘要:本发明涉及新型鬼笔环酯衍生物及其荧光染料偶联物.这些新化合物可用于研究活体系统中的肌动蛋白动力学.本发明还涉及制备这类化合物的方法.合成路线结合了固相和溶液相肽合成,对于高效制备多样化的鬼笔环酯衍生物文库具有巨大优势,尤其适用于鬼笔环酯的合成.

专利信息

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:WO-2023044581-A1
优先权日:2021-09-24
标题 :Flow synthesis of porous collagen microparticles for versatile tissue engineering applications
发明人：SINGH SUSHANT; SAMIEI EHSAN; GUENTHER AXEL; VERES TEODOR
权利人:GOVERNING COUNCIL UNIV TORONTO; NAT RES COUNCIL CANADA; SINGH SUSHANT
摘要:A microfluidic flow synthesis method for collagen-based microparticles. Macro-porous fibrillar microparticles of pure collagen and composite collagen-GAG were formed, where the particle size and porosity were controlled by the flow synthesis parameters such as precursor flow rates. Using human dermal fibroblasts (hDFB) and umbilical cord derives mesenchymal stem cells (ucMSC), the capacity of the presented collagen and collagen-GAG microparticles to serve as cell culture substrates has been shown, to enable casting of tissues, forming spheroids, and as shear-thinning bioinks for bioprinting. At high packing densities, jammed collagen-based microparticles along with cells constitute a shear-thinning bioink for extrusion bioprinting applications. Bioprinted constructs exhibit a high porosity matrix due to the space between the microparticles, facilitating macromolecular transport, and cell proliferation and migration.

专利号:US-2025235415-A1
优先权日:2022-02-23
标 题:Modulation of human breast milk composition
发明人：ROSS MICHAEL G; DESAI MINA
权利人:LUNDQUIST INST FOR BIOMEDICAL INNOVATION AT HARBOR UCLA MEDICAL CENTER
摘要:Compositions and methods for improving a child, such as an infant's health, are provided. The methods entail improving the quality of breast milk in a female human individual that provides breast milk, or expects to provide breast milk, to the child, by administering to the individual an agent that increases the individual's sensitivity to insulin, and/or an agent that reduces the substrate uptake, synthesis or secretion of long chain fatty acids, reduces the substrate uptake, synthesis or secretion of short chain fatty acids, increases the amino acid uptake, protein synthesis or protein secretion of proteins, or reduces the uptake or synthesis of lactose.

专利号:US-8569452-B2
优先权日:2011-02-17
标题:Preparation of phalloidin and its derivatives
发明人：LIU BAOSHENG; ZHANG JIANHENG
权利人:LIU BAOSHENG; ZHANG JIANHENG; AMERICAN PEPTIDE COMPANY INC
摘要:The present invention relates to novel phalloidin derivatives and their fluorescent dye conjugates. These new compounds may be used in studies of actin dynamics in living systems. The present invention also relates to methods for preparing such compounds. The synthesis routes combine solid-phase and solution phase peptide synthesis, and has great advantage for efficient preparation of a diverse library of the phalloidin derivatives, especially for the synthesis of phalloidin.

专利号:US-9732112-B2
优先权日:2010-05-28
标 题:Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization
发明人：MA ZHAOCHUN; MULLAH KHAIRUZZAMAN BASHAR; EASON ROBERT G
权利人:LIFE TECHNOLOGIES CORP
摘要:Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.

专利号:US-9932582-B2
优先权日:2014-01-14
标题 :Materials and methods for modulation of tendon healing
发明人：GILCHRIST DEREK STEWART; MILLAR NEAL LINDSAY
权利人:UNIV GLASGOW COURT
摘要:The invention relates to the use of microRNA 29 and precursors and mimics thereof for the modulation of tendon injury and the biomechanical properties of tendon. In particular, the invention derives from the finding that synthesis of type 1 collagen in tenocytes is less sensitive to miR-29 than is synthesis of type 3 collagen, thus enabling the balance between the collagen subtypes to be modulated in favor of type 1 collagen, mitigating reduction in biomechanical properties during healing.