CAS: 17337-13-2; 2-Biphenylylisocyanate

上下游产品

CAS号17763-65-4 (2-phenylphenyl... | CAS号917-61-3 氰酸钠 | CAS号947-84-2 2-苯基苯甲酸 | CAS号75-44-5 光气 | CAS号90-41-5 2-氨基联苯 | CAS号86-00-0 2-硝基联苯 | CAS号32315-10-9 三光气 | CAS号13262-46-9 (2-phenylphenyl)urea | CAS号171722-92-2 4-哌啶基 (2-联苯基)氨基甲酸酯 | CAS号171723-80-1 (1-benzylpiperi... | CAS号40713-47-1 N-(2-Biphenylyl...

二氢-3-(异十二碳烯基)呋喃-2,5-二酮置于二苯基膦叠氮化物,三乙胺体系中,用 甲苯 用作溶剂,化学反应 0.33H,反应生成异氰酸2-联苯酯
参考文献:选择性毒蕈碱拮抗剂.二.联苯基氨基甲酸酯衍生物的合成及其抗毒蕈碱特性.
标题:选择性毒蕈碱拮抗剂.二.联苯基氨基甲酸酯衍生物的合成及其抗毒蕈碱特性.
摘要:合成了一系列新颖的联苯基氨基甲酸酯衍生物,并评估了与m1,M2和m3受体的结合以及抗毒蕈碱活性.受体结合试验表明,联苯-2-基氨基甲酸酯衍生物对m1和m3受体具有高亲和力,对m3受体的选择性高于m2受体,表明联苯-2-基是毒蕈碱中二苯甲基的新型疏水替代物.拮抗剂领域.在这个系列中,奎宁环丁-4-基联苯基-2-基氨基甲酸酯一盐酸盐(8L,Ym-46303)对m1和m3受体的亲和力最高,对m3的选择性高于m2受体.与奥昔布宁相比,Ym-46303在反射性节律性收缩中对膀胱压力的抑制活性约高十倍,对大鼠唾液分泌的膀胱收缩选择性提高约5倍.此外,在体外也观测到选择性拮抗活性.对成年大鼠心动过缓和升压以及小鼠震颤的抗毒蕈碱作用的进一步评估表明,Ym-46303可作为膀胱选择性m3拮抗剂用于尿急性尿失禁的治疗,具有有效的作用和较少的副作用.
Doi:10.1248/cpb.46.1286

专利信息

专利号:US-11655255-B2
优先权日:2022-10-17
标题 :Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
发明人：ZHANG WANBIN; WANG MO; ZHANG LU; HUO XIAOHONG; ZHANG ZHENFENG; YUAN QIANJIA; CHEN JIANZHONG
权利人:SPH NO 1 BIOCHEMICAL & PHARMACEUTICAL CO LTD; UNIV SHANGHAI JIAOTONG
摘要:A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-9035061-B2
优先权日:2010-07-13
标题:Process for preparing a biphenyl-2-ylcarbamic acid
发明人：COLSON PIERRE-JEAN
权利人:COLSON PIERRE-JEAN; THERAVANCE BIOPHARMA R & D IP LLC
摘要:The invention provides a process of preparing an intermediate useful in the synthesis of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and a process of preparing a crystalline freebase of the ester.

专利号:US-2023085986-A1
优先权日:2022-10-17
标 题:Method for catalytic asymmetric synthesis of phosphorus-stereogenic (p-stereogenic) nucleoside derivative and catalyst used therein