CAS: 16652-76-9; H-Val-Obzl.Tosoh

相似化合物

17662-84-9 16652-75-8 1738-77-8

上下游产品

CAS号72-18-4 l-缬氨酸 | CAS号104-15-4 对甲苯磺酸 | CAS号100-51-6 苯甲醇 | CAS号4070-48-8 L-缬氨酸甲酯 | CAS号21760-98-5 L-缬氨酸苄酯 | CAS号72-18-4 l-缬氨酸 | CAS号13588-95-9 (S)-2-((S)-2-氨基... | CAS号122299-14-3 eglin c (60-63) | CAS号3918-94-3 缬氨酰-缬氨酸

N-(二苯基亚甲基)-L-缬氨酸甲酯置于sodium Hydroxide,四丁基硫酸氢铵体系中,用 水,乙腈 用作溶剂,化学反应 22.0H,反应生成L-缬氨酸苄酯对甲苯磺酸盐
参考文献:Oxygen Alkylation Of Schiff Base Derivatives Of Amino Acids
标题:Oxygen Alkylation Of Schiff Base Derivatives Of Amino Acids
摘要:氨基酸和二肽的高亚胺酯1A-H和7A-B通过皂化苯甲酮席夫碱甲酯3A-D和6,采用相转移技术,随后与烷基卤进行o-烷基化,产率在68-91%之间.该过程在α-碳上保留构型,除了苯基甘氨酸衍生物外.
Doi:10.1055/s-1991-26625

专利信息

专利号:EP-1831186-B1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan
发明人：ZUPANCIC SILVO; PECAVAR ANICA; ZUPET ROK
权利人:KRKA D D NOVO MESTO
摘要:This invention relates to an improved process for preparing a valsartan, or a pharmaceutically acceptable salt thereof, or pharmaceutical preparation containing either entity wherein a compound of formula (II) nor a salt thereof, is reacted with valine or an ester or a salt thereof in a solvent selected from the group consisting of methylene chloride, chloroform, butyl chloride, isopropyl acetate and tert -butyl methyl ether to form a compound of formula (IV) nwhich is then acylated to form a compound of formula (VI) nwherein R is hydrogen, alkyl, alkenyl or benzyl; which is then deprotected to give valsartan, and may be converted to a pharmaceutically acceptable salt and/or a pharmaceutical formulation. The invention also covers intermediates of formula (IV) and (VI) wherein R=H.

专利号:WO-2006058701-A1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan

专利号:EP-1831186-A1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan

专利号:EP-1661891-A1
优先权日:2004-11-30
标 题 :A process for the synthesis of valsartan

专利号:US-6858585-B1
优先权日:1996-06-25
标题 :Cyclic depsipeptides and drugs containing the same as the active ingredient
发明人：YANAI MAKOTO; SUZUKI MASASHI; OSHIDA NORIO; KAWAMURA KOJI; HIRAMOTO SHIGERU; YASUDA ORIE; KINOSHITA NOBUHIRO; SHINGAI AKIKO; TAKASU MASAKO
权利人:NISSHIN SEIFUN GROUP INC
摘要:Cyclic depsipeptides represented by the formula n n nwherein:n n R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.

专利号:CN-102241674-A
优先权日:2010-05-12
标题 :Synthesis and Antitumor Activity Evaluation of 1,1-Dimethyl-β-carboline-3-formyl Amino Acid Benzyl Ester