CAS: 1533426-72-0; 5,6-Bis(((E)-Benzylidene)Amino)-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One
- 英文名称5,6-Bis(((E)-Benzylidene)Amino)-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One
- 中文名称2,3-二氢-5,6-二[(E)-(苯基亚甲基)氨基]-2-硫代-4(1H)-嘧啶酮
- IUPAC名称5,6-bis(((E)-benzylidene)amino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
- 其它别名4(1H)-Pyrimidinone, 2,3-Dihydro-5,6-Bis[(Phenylmethylene)Amino]-2-Thioxo-; Scr7; 2,3-Dihydro-5,6-Bis[(E)-(Phenylmethylene)Amino]-2-Thioxo-4(1H)-Pyrimidinone; 7-Benzyl-4-(2-Methylbenzyl)-2,4,6,7,8,9-Hexahydroimidazo
- CAS编号1533426-72-0
- MFCD编号:MFCD28900670
- 分子式:C18H14N4OS分子量:334.4
- 产品CID: 752984
- 产品分类Inhibitors/Agonists → Cell Cycle → DNA/RNA Synthesis | Inhibitors/Agonists → Cell Cycle → DNA/RNA Synthesis
物理性质
- 熔点206-208°C
- 密度1.27±0.1 g/cm3(预测)
- pKa:7.93±0.25(预测)
- PSA:105.46
- LogP:3.9337
- 溶解性DMSO (Slightly), Methanol (Slightly)
- 外观形态淡黄色固体
- 储存条件储存在 -20°C
- 产品应用该化合物是一种特定的DNA液态四氯酸酯抑制剂,可阻断无血端结合(NHEJ);它有效抑制以200微米及以上浓度形成多胞胎;它抑制NHEAJ修复CRISPR-CAS9引起的双层断层和间歇(DSBS);它抑制细胞在MCF7,A549,HELA,T47D,A2780,HT1080和NALM6细胞中的扩散,其IC50值分别为40,34,44,48,8.5,120,10和50微米;在体内,SCR-7(10毫克/千克,一米)显著减少乳腺癌引起的肿瘤生长,并将寿命延长四倍于控制组;在BALB/C小鼠中,SCRE7(20毫克/公斤,一.P.)显著增强辐射,ETOPOSIDE和3-MONIGENZAMIDE对DALDAL-PHHOMA(DLA)细胞源肿瘤的细胞毒性影响.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: John F, George J, Srivastava M, Hassan PA, Aswal VK, Karki SS, Raghavan SC. Pluronic copolymer encapsulated SCR7 as a potential anticancer agent. Faraday Discuss. 2015 Jan 21. [Epub ahead of print] doi: 10.1371/journal.pone.0068088. Print 2013.
4: Srivastava M, Nambiar M, Sharma S, Karki SS, Goldsmith G, Hegde M, Kumar S, Pandey M, Singh RK, Ray P, Natarajan R, Kelkar M, De A, Choudhary B, Raghavan SC. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012 Dec 21;151(7):1474-87. doi: 10.1016/j.cell.2012.11.054. doi: 10.1074/jbc.M110.143727. Epub 2010 Sep 20.
6: Deban L, Jarva H, Lehtinen MJ, Bottazzi B, Bastone A, Doni A, Jokiranta TS, Mantovani A, Meri S. Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation. J Immunol. 2008 Dec 15;181(12):8433-40. doi: 10.1016/j.molimm.2008.01.027. Epub 2008 Mar 12. Epub 2007 Jun 20.
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