📜对硝基肉桂酸置于氯化亚砜体系中,用 苯 用作溶剂,化学反应生成4-硝基肉桂醇 参考文献:The Ortho-Claisen Rearrangement. Iv. The Rearrangement Of X-Cinnamyl P-Tolyl Ethers1 标题:The Ortho-Claisen Rearrangement. Iv. The Rearrangement Of X-Cinnamyl P-Tolyl Ethers1 摘要: Doi:10.1021/ja01479A026
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-6172226-B1 优先权日:1993-12-22 标 题:Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions 发明人:COULL JAMES M; EGHOLM MICHAEL; HODGE RICHARD P; ISMAIL MOHAMED; RAJUR S B 权利人:PERSEPTIVE BIOSYSTEMS INC 摘要:A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.
专利号:US-2006264622-A1 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines
专利号:WO-2005023814-A1 优先权日:2003-09-11 标 题 :Synthesis of protected pyrrolobenzodiazepines
专利号:EP-1873156-A1 优先权日:1995-06-07 标 题:Process for the preparation of 6-[[(alkoxy)carbonyl]amino]-9H-Purine-9-acetic acid and 4-[(alkoxycarbonyl)amino]-2-oxo-1(2H)-Pyrimidineacetic acid derivatives as synthons for the synthesis of peptide nucleic acids
专利号:EP-1664049-B1 优先权日:2003-09-11 标 题 :Synthesis of protected pyrrolobenzodiazepines
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