专利号:US-8338621-B2 优先权日:2005-12-21 标题:Process for the preparation of 2-oxo-1-pyrrolidine derivatives 发明人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY 权利人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY; UCB SA 摘要:The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) n n n n n n n n n n Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.
专利号:US-6797479-B2 优先权日:1995-04-04 标题 :Reagents and methods for the detection and quantification of vancomycin in biological fluids 发明人:ADAMCZYK MACIEJ; BRATE ELAINE M; PERKOWITZ MARY M; REGE SUSHIL D 权利人:ABBOTT LAB 摘要:Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of FIG. 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of FIG. 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.
专利号:WO-9213530-A1 优先权日:1991-02-11 标题 :Transglutaminase enzyme inhibitors 发明人:CHEN GEORGE T 权利人:MEDICIS CORP 摘要:The present invention relates to a composition and method for regulating protein crosslinking by transglutaminase enzymes in an animal or human. More particularly, the present invention relates to a series of novel transglutaminase enzyme inhibitors having the general formula: R-C=O-(CH2)n-NCS, wherein R is selected from the group consisting of O-CH3, O-CH2-CH3, O-Ø, O-Bz, and NH2 and n is an integer between 1 and 4, to their synthesis, and to their use in the treatment of crosslinking and amine incorporation disorders.
专利号:CN-105399711-A 优先权日:2015-11-13 标 题 :A kind of synthesis method of carbofuran carboxylated hapten
专利号:CN-105399711-B 优先权日:2015-11-13 标题 :A kind of synthesis method of carbofuran carboxylated hapten
专利号:US-6472403-B2 优先权日:2000-01-20 标 题 :αV integrin receptor antagonists 发明人:DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; LI AIWEN; MEISSNER ROBERT S; PERKINS JAMES J; STEELE THOMAS G; WANG JIABING; PATANE MICHAEL A 权利人:MERCK & CO INC 摘要:The present invention relates to novel imidazolidinone derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
[参考文献]: I N Tiurenkov, Et Al. [参考文献]: Farmakol Toksikol. 1986 Nov-Dec;49(6):31-4. [参考文献]: Michael R Emmett, Et Al. Tandem Ring-Opening Decarboxylation Of Cyclopropane Hemimalonates With Sodium Azide: A Short Route To γ-Aminobutyric Acid Esters. J Org Chem. 2012 Aug 3;77(15):6634-7.
合成参考文献
摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 478. 摘要:Biochemical Pharmacology., 32(1093), 1983 []