CAS: 128694-63-3; 1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-5-Carboxylic Acid

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CAS号71-48-7 乙酸钴 | CAS号638-38-0 乙酸锰(II) | CAS号79080-31-2 1,5-二甲基-3-(三氟甲基... | CAS号154471-65-5 1-甲基-3-三氟甲基-1H-吡唑 | CAS号124-38-9 二氧化碳 | CAS号129768-30-5 5-三氟甲基-2H-吡唑-3-甲酸乙酯 | CAS号128694-71-3 4-chloro-1-meth... | CAS号949898-58-2 1-甲基-3-(三氟甲基)- ...

📜5-(2-Furyl)-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole置于ruthenium Trichloride,Sodium Periodate体系中,用 四氯化碳,水,乙腈 用作溶剂,化学反应 0.08H,以87%的收率获得2-甲基-5三氟甲基-2H-吡唑-3-羧酸
参考文献:通过使用氟化的醇作用作溶剂提高吡唑形成中的区域选择性:氟化的tebufenpyrad类似物的合成和生物活性
标题:通过使用氟化的醇作用作溶剂提高吡唑形成中的区域选择性:氟化的tebufenpyrad类似物的合成和生物活性
摘要:The Preparation Of N-Methylpyrazoles Is Usually Accomplished Through Reaction Of A Suitable 1,3-Diketone With Methylhydrazine In Ethanol As The Solvent. This Strategy,However,Leads To The Formation Of Regioisomeric Mixtures Of N-Methylpyrazoles,Which Sometimes Are Difficult To Separate. We Have Determined That The Use Of Fluorinated Alcohols Such As 2,2,2-Trifluoroethanol (Tfe) And 1,1,1,3,3,3-Hexafluoro-2-Propanol (Hfip) As Solvents Dramatically Increases The Regioselectivity In The Pyrazole Formation,And We Have Used This Modification In A Straightforward Synthesis Of Fluorinated Analogs Of Tebufenpyrad With Acaricide Activity.
Doi:10.1021/jo800251G