CAS: 12707-58-3; Disialoganglioside Gd1A From Bovine Brain

专利信息

专利号:US-7608442-B2
优先权日:1999-02-01
标题:β1,3-galactosyltransferase polypeptides from the LOS locus of C. jejuni
发明人：GILBERT MICHEL; WAKARCHUK WARREN W
权利人:CA NAT RESEARCH COUNCIL
摘要:This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni . In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

专利号:US-9157105-B2
优先权日:2008-12-16
标 题:Biosynthesis of CMP-legionaminic acid from fructose-6-P, and respective pathway intermediates, using novel GDP-linked precursors
发明人：SCHOENHOFEN IAN C; LOGAN SUSAN M
权利人:SCHOENHOFEN IAN C; LOGAN SUSAN M; NAT RES COUNCIL CANADA
摘要:The sialic acid-like sugar legionaminic acid is found as a virulence-associated surface glyco-conjugate in Legionella pneumophila and Campylobacter coli . In this work, we have purified and biochemically characterized eleven candidate biosynthetic enzymes from C. jejuni , thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P. This pathway involves unique GDP-linked intermediates and provides a facile means for the efficient large-scale synthesis of an important sialic acid mimic and novel precursors.

专利号:WO-9425615-A1
优先权日:1993-05-04
标 题 :USE OF TRANS-SIALIDASE AND SIALYLTRANSFERASE FOR SYNTHESIS OF SIALYLα2→3βGALACTOSIDES

专利号:US-7371838-B2
优先权日:1999-02-01
标 题 :Nucleic acids encoding β 1,4-N-acetylgalactosaminyltransferases from C. jejuni
发明人：GILBERT MICHEL; WAKARCHUK WARREN W
权利人:CA NAT RESEARCH COUNCIL
摘要:This invention provides prokaryotic β1,4-N-acetylglucosaminyl (GalNAc) traosferases involved in synthesis of lipooligosaccharide (LOS). The β1,4-GalNAc transferases can be obtained from, for example, Campylobacter species, including C. jejuni . In additional embodiments, the invention provides nucleic acids that encode the β1,4-GaINAc transferases, as well as expression vectors and host cells for expressing the β1,4-GalNAc transferases.

专利号:US-12239652-B2
优先权日:2018-08-24
标题 :Composition for preventing or treating muscular diseases, or for improving muscular functions, containing ganglioside
发明人：HWANG JAE KWAN; SU SEUNG TAE; KIM JONG WOOK; KIM CHANG HEE; YOO JI HEE
权利人:UNIV YONSEI IACF; IND ACADEMIC COOPERATION FOUNDATION YONSELUNIVERSITY
摘要:The present invention relates to a composition for preventing or treating muscular diseases, or for improving muscular functions, containing gagnlioside. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating muscular diseases, a food composition for preventing or alleviating muscular diseases, or a cosmetic composition for preventing or alleviating muscular diseases, all of which comprise gagnlioside, which can increase the expression of proteins associated with muscle protein synthesis and muscle mass growth in muscle cells and inhibit the expression of enzymes involved in muscle protein degradation at the mRNA level.

专利号:US-2010248365-A1
优先权日:2009-03-27
标 题:Ganglioside biosynthesis modulators
发明人：CRAWFORD BRETT E; GLASS CHARLES A; BROWN JILLIAN R; BAI XIAOMEI
权利人:ZACHARON PHARMACEUTICALS INC
摘要:Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation.