CAS: 102684-91-3; 2-Bromo-5-(Trifluoromethyl)Benzaldehyde

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1483-56-3 869725-53-1 1214336-55-6

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CAS号1483-55-2 2-溴-5-三氟甲基苯腈 | CAS号869725-53-1 2-溴-5-三氟甲基苄醇 | CAS号869725-56-4 2-溴-5-(三氟甲基)苯丙酸 | CAS号869725-53-1 2-溴-5-三氟甲基苄醇 | CAS号150969-56-5 5-三氟甲基-1-茚酮 | CAS号201929-84-2 5-(三氟甲基)-1H-吲哚-... | CAS号869725-54-2 2-溴-5-(三氟甲基)氯苄 | CAS号869725-57-5 5-三氟甲基二氢-1-茚醇

📜2-溴-5-三氟甲基苄醇置于戴斯-马丁氧化剂体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,以99%的收率获得3-氟-5-甲氧基苯甲醛
参考文献:氢键催化和简单溶剂在糖醛环氧化物立体选择性动力学环氧化物开环螺环化形成螺缩酮中的抑制作用
标题:氢键催化和简单溶剂在糖醛环氧化物立体选择性动力学环氧化物开环螺环化形成螺缩酮中的抑制作用
摘要:对 Meoh 诱导的糖醛环氧化物动力学环氧化物开环螺环化的机理研究揭示了简单溶剂在该反应的氢键催化中具有显着的特定作用,以立体选择性地形成螺缩酮产物,并在异头碳上发生构型反转.一系列电子调谐的 C1-芳基乙二醇环氧化物用于研究该反应的机理,该反应基于不同的反应速率和 S(N)2 与 S(N)1 反应歧管的固有偏好.对这些底物的反应动力学的 Hammett 分析与 S(N)2 或 S(N)2 样机制一致(对于这些底物的相应 S(N)1 反应,ρ =-1.3 Vs ρ =-5.1).值得注意的是,螺环化反应二级依赖于甲醇,二级甲醇催化需要糖环氧.然而,丙酮助溶剂是反应的一级抑制剂.提出了与实验数据一致的过渡态,其中一当量的 Meoh 通过氢键激活环氧化物亲电试剂,而第二当量的 Meoh 螯合侧链亲核试剂和糖环氧.一个自相矛盾的先前观察结果,即降低 Meoh 浓度导致竞争性分子间甲基糖苷形成增加,通过发现该副反应仅一级依赖于
Doi:10.1021/ja201249C

专利信息

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:WO-2012085133-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof

专利号:US-2014135368-A1
优先权日:2010-12-23
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof

专利号:WO-2025119326-A1
优先权日:2023-12-07
标 题 :Novel prmt5 inhibitor and use thereof
发明人：YAO BING; WANG MINGHUA; ZHANG JUNQING; GU XIAOHUI; XIE SHANSHAN; CHENG KAI
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:The present disclosure describes novel molecules with protein arginine methyltransferase 5 inhibitory activity, and methods for synthesis and use of the compound. Specifically, the present disclosure describes the compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and methods for synthesis and use of the compound.