CAS: 952-97-6; (4-Nitrophenyl)(Phenyl)Sulfane

该化合物是一种有机硫化合物,其特征是连接硝基苯和苯基组的硫化物链接,黄晶状固体主要用作有机合成的中间体,特别是在准备含有硫的乙型循环和作为功能化芳香化合物的前体时;其硝基化合物组增强了核球动力替代反应的回性,使其对建造复杂的分子结构具有价值;该化合物在标准条件下表现出中度稳定性,在普通有机溶剂中可溶解,便于在实验室环境中处理;其明确界定的结构和可预测的再活动特征有助于其在制药和材料科学研究应用中的效用.

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CAS号636-98-6 4-硝基碘苯 | CAS号108-98-5 硫酚 | CAS号586-78-7 对溴硝基苯 | CAS号882-33-7 二苯二硫醚 | CAS号955-45-3 1-(benzenesulfi... | CAS号100-00-5 对硝基氯苯 | CAS号591-50-4 碘苯 | CAS号1849-36-1 4-硝基苯硫酚 | CAS号350-46-9 对氟硝基苯 | CAS号100-32-3 4,4'-二硝基二苯二硫醚 | CAS号106380-90-9 3-phenylsulfany... | CAS号14453-89-5 1-[4-(4-aminoph... | CAS号21229-95-8 4-(benzenesulfi... | CAS号1146-39-0 4-硝基联苯砜 | CAS号1135-14-4 4-(苯硫基)苯胺 | CAS号860726-25-6 bis-(4-phenylsu... | CAS号7019-01-4 4-苯磺酰基苯胺 | CAS号72301-69-0 2-(2-nitro-5-ph... | CAS号88519-49-7 1-iodo-4-phenyl... | CAS号89278-19-3 tert-butyl 2-(2...

合成工艺路线路线简述

    📜4-硝基苯亚磺酰氯置于potassium Carbonate,间氯过氧苯甲酸体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 4-硝基苯基苯硫
    参考文献:吡咯的硫基保护基和2-(2,4-二硝基苯)亚磺酰基和磺酰基吡咯的轻松脱保护
    标题:吡咯的硫基保护基和2-(2,4-二硝基苯)亚磺酰基和磺酰基吡咯的轻松脱保护
    摘要:简单的亚磺酰基和磺酰基作为吡咯的吸电子保护基的有效性已使用13 C NMR光谱法进行了分析,并通过考虑x射线晶体结构得到了证实.另外,已表明2,4-二硝基苯亚磺酰基和磺酰基是吡咯的有效的吸电子保护基,它们可以通过在温和和特定条件下用苯硫醇或硫醇盐处理而除去.
    DOI:10.1021/jo050077B

    海关参考信息

    专利信息


    专利号:US-7531694-B2
    优先权日:2004-07-07
    标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone
    发明人：VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO
    权利人:LUNDBECK PHARMACEUTICALS ITALY
    摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

    专利号:US-2008293970-A1
    优先权日:2004-07-07
    标 题:Process for Synthesis of 4-4'-Diamino-Diphenyl-Sulfone

    专利号:WO-2006002690-A1
    优先权日:2004-07-07
    标 题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone

    专利号:US-4511729-A
    优先权日:1982-04-30
    标 题 :Nucleophilic substitution process
    发明人：STAHLY G PATRICK; STAHLY BARBARA C
    权利人:ETHYL CORP
    摘要:Nitrophenoxy- or nitrophenylthiobenzeneacetic acid esters are prepared by reacting a nitrophenoxy- or nitrophenylthiobenzene with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base. The products are useful as intermediates for the synthesis of pharmaceuticals, such as fenoprofen.

    专利号:US-4502998-A
    优先权日:1982-08-25
    标题 :Nucleophilic substitution process
    发明人：STAHLY BARBARA C; STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Nitrophenoxy- or phenylthiobenzeneacetonitriles are prepared by reacting a nitrophenoxy- or nitrophenylthiobenzene with an alpha,alpha-dinitrosubstituted acetonitrile in an inert solvent and in the presence of a base. The products are useful as intermediates for the synthesis of pharmaceuticals, such as fenoprofen.

    专利号:BR-PI0711208-A2
    优先权日:2006-05-19
    标 题 :compounds, intermediates for the synthesis of compounds, process, pharmaceutical composition, use of a compound and uses

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    主要参考文献

    参考标题:Efficient Copper(I)-Catalyzed C-S Cross-Coupling Of Thiols With Aryl Halides In An Aqueous Two-Phase System
    作者:Xin-Yan Zhang,Xiao-Yan Zhang,Sheng-Rong Guo |发布日期:2011.2.1
    摘要:A Mild And Convenient C-S Bond Formation Reaction Catalyzed By Cui/l-Proline In An Aqueous Two-Phase System Was Achieved, Providing A Simple Method For The Synthesis Of Aryl Sulfides In Good Yields.

    合成参考文献


    摘要:Baker, A.; Wirth, T., Science of Synthesis Knowledge Updates, (2017) 1, 199.
    摘要:Chanda, A.; Fokin, V. V., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 722.
    摘要:Eichman, C. C.; Stambuli, J. P., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 391.
    摘要:Ronson, T. O.; Fairlamb, I. J. S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 187.
    摘要:Ronson, T. O.; Fairlamb, I. J. S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 191.
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