CAS: 91374-21-9; 4-(2-(Dipropylamino)Ethyl)Indolin-2-One

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CAS号76149-15-0 N-[2-(1H-indol-... | CAS号91374-25-3 2-[2-(二丙基氨基)乙基]... | CAS号720656-64-4 2-(2-N,N-二丙基氨基乙... | CAS号1975-50-4 2-甲基-3-硝基苯甲酸 | CAS号23876-13-3 2-甲基-3-硝基苯甲醇 | CAS号23876-15-5 2-甲基-3-硝基苯乙酸 | CAS号23876-14-4 2-甲基-3-硝基苯乙腈 | CAS号81654-62-8 4-[2-(dipropyla... | CAS号60468-54-4 2-甲基-3-硝基苄氯 | CAS号101566-00-1 (2-METHYL-3-NIT... | CAS号91374-20-8 盐酸罗匹尼罗

在 Sodium Hydroxide,水体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 累匹利洛
参考文献:Novel Process For Ropinirole Preparation
标题:Novel Process For Ropinirole Preparation
摘要:一种用于制备以下化合物的方法:其中r2选自氨基,低烷基氨基,二烷基氨基,烯丙氨基,二烯丙氨基,N-烷基-N-烯丙氨基,苄氨基,二苄氨基,苯乙基氨基,二苯乙基氨基,4-羟基苯乙基氨基或二-(4-羟基苯乙基氨基)等基团的方法;包括:A)将与wittig试剂反应以产生其中r1为烷氧基;f)在酸性条件下水解化合物ii以产生g)将化合物iii进行还原和胺化以产生三级胺,其中r2如上所定义;h)将化合物iv与4-氯苯氧乙腈反应,进行亲核取代以产生腈化合物,其中r2如上所定义;并i)在同一步骤中使用钯/c和氢氧化钠进行还原和水解以产生其中r2如上所定义.

专利信息

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-11766432-B2
优先权日:2018-07-27
标题 :Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same
发明人：BENTLEY MICHAEL; FANG ZHIHAO; WEIMER REBECCA; VIEGAS TACEY; MOREADITH RANDALL
权利人:SERINA THERAPEUTICS INC
摘要:Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.

专利号:US-2008125354-A1
优先权日:2005-11-21
标题 :Selective inhibition of matrix metalloproteinases
发明人：FIELDS GREGG B; HAMMER ROBERT
权利人:UNIV FLORIDA ATLANTIC; UNIV LOUISIANA STATE
摘要:Synthetic triple-helical peptides (THPs) are used for the design and synthesis of triple-helical transition state analog inhibitors. These inhibitors feature a phosphonate ester or phosphinic moiety in place of the scissle bond. These groups inhibit MMPs, and methods been developed for their convenient incorporation within a peptide sequence by solid-phase methods.

专利号:WO-2025128098-A1
优先权日:2023-12-13
标 题 :Solid oral dosage forms, kits, and methods of using the same
发明人：LI YING; LANGER ROBERT; TRAVERSO CARLO
权利人:MASSACHUSETTS INST TECHNOLOGY; BRIGHAM & WOMENS HOSPITAL INC
摘要:Provided herein are solid oral dosage forms, methods, and kits useful, e.g, for the extension of the residence time of active pharmaceutical agents in vivo by the synthesis of a polymer in situ in a subject. In particular, the solid oral dosage forms, methods, and kits disclosed herein are particularly useful for drugs that require more than once daily administration (e.g, drugs that have short half-lives).

专利号:US-7919505-B2
优先权日:2006-07-11
标题 :Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
发明人：TING PAULINE C; LEE JOE F; FENG KUNG-I; REEDER MICHAEL R; TRZASKA SCOTT T; ZHU MAN; MAO CHEN; FILIPOV DIMITAR L; ZARKADAS DIMITRIOS N
权利人:SCHERING CORP
摘要:The present invention relates to the compound of the formula n nTo methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.

专利号:US-2011003780-A1
优先权日:2007-07-10
标题:Hydrogen chloride salt of a substituted 5-oxazol-2-yl-quinoline compound and a process for the production thereof
发明人：ZHU MAN
权利人:SCHERING CORP
摘要:The present invention relates to the compound of the Formula I: n n n n n n n n n n and to methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to a particular crystalline form and processes of synthesis of the crystalline form. n IM=105109