CAS: 85068-32-2; 2-(3,5-Bis(Trifluoromethyl)Phenyl)Acetonitrile

上下游产品

3,5-(bistrifluoromethyl)chlorobenzene cyanoacetic acid 3,6-bis(trifluoromethyl)bromobenzene sodium cyanoacetate cyclopentanecarbonitrile1-3,5-Bis(trifluoromethyl)phenylcyclopentanecarbonitrile (3,5-bis-trifluoromethylphenyl)-bromo-acetonitrile

在 甲醇体系中,化学反应生成 3,5-双(三氟甲基)苯乙腈
参考文献:Carbanion Reactivity; Kinetics Of The Reactions Of Benzyl Cyanide Anions With Aromatic Nitro-Compounds
标题:Carbanion Reactivity; Kinetics Of The Reactions Of Benzyl Cyanide Anions With Aromatic Nitro-Compounds
摘要:Rate And Equilibrium Measurements Are Reported For The Reactions In Methanol Of Carbanions Derived From 12 Ring-Substituted Benzyl Cyanides With 1,3,5-Trinitrobenzene To Give Sigma-Adducts. Some Data For Reaction Of The Carbanions With 4-Nitrobenzofuroxan Were Also Measured. With Increasing Carbanion Reactivity,Rate Constants Approach A Limit Of Just Below 10(9) Dm(3) Mol(-1) S(-1). Intrinsic Reactivities Of Carbanions In Sigma-Adduct Forming Transfer Reactions Are Compared.
DOI:10.1039/p29950000443

专利信息

专利号:US-9428490-B2
优先权日:2011-07-29
标 题 :Nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD
权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD; KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.