CAS: 7695-91-2; 2,5,7,8-Tetramethyl-2-(4,8,12-Trimethyltridecyl)Chroman-6-Yl Acetate

上下游产品

3,5,6-trimethyl-2-phytylhydroquinone acetic anhydride vitamin E α-t°Cotrienolvitamin E Duroquinone N-(phenylmethyl)acetamide

(All-Rac)-Acetic Acid 4-Hydroxy-2,3,6-Trimethyl-5-[3-(4,8,12-Trimethyltridecyl)-But-3-Enyl]Phenyl Ester置于对甲苯磺酸体系中,用 碳酸丙烯酯,正庚烷 作为反应溶剂,化学反应 1.5H,以98.5%的收率获得产物dl-α-生育酚醋酸酯
参考文献: Manufacture Of Tocopheryl Acetate[fr] Fabrication D'Acetate De Tocopheryle
标题: Manufacture Of Tocopheryl Acetate[fr] Fabrication D'Acetate De Tocopheryle
摘要:一种制备3-辅酰基-2,5,6-三甲基对羟基苯甲酸-1-乙酸酯的工艺,以及可选择性地由此制备生育酚乙酸酯,包括将2,3,6-三甲基对羟基苯甲酸-1-乙酸酯在含有符合r1So2Oh式的硫(Vi)催化剂的无极性有机溶剂中与异生育醇或生育醇进行c-烷基化,其中r1表示羟基,卤素,低烷基,卤代低烷基或芳基,或者在极性无极性有机溶剂中,在碱的存在下,将2,3,6-三甲基对羟基苯甲酸-1-乙酸酯与生育醇卤化物进行o-烷基化,并将所得的4-O-生育醇-2,3,6-三甲基对羟基苯甲酸-1-乙酸酯进行重排反应,然后可选择性地将所得的3-辅酰基-2,5,6-三甲基对羟基苯甲酸-1-乙酸酯进行环闭合反应以产生生育酚乙酸酯.该发明还包括新型化合物3-辅酰基-2,5,6-三甲基对羟基苯甲酸-1-乙酸酯及其某些立体异构体,以及进一步的新型化合物4-羟基-2,3,6-三甲基-5-[3-(4,8,12-三甲基十三烷基)-丁-3-烯基]苯乙酸酯,它本身是在受热影响下异构化形成的3-辅酰基-2,5,6-三甲基对羟基苯甲酸-1-乙酸酯的若干异构体之一,例如在其作为随后其制备过程中的分离和纯化过程的一部分的蒸馏过程中.从其乙酸酯中提取的(全反)-α-生育醇被认为是维生素e类中最活跃的工业重要成员.

专利信息

专利号:WO-9617589-A1
优先权日:1994-12-08
标 题 :Method of smoothing or removing wrinkles and method of stimulating collagen synthesis
发明人：FUJIMURA TSUTOMU; OGAWA AYUMI; OHSU HIROYUKI; TAKEMA YOSHINORI; HORI KIMIHIKO; AMANO SHINYA; FUJIMORI TAKETOSHI; OHASHI YUKIHIRO; SUZUKI YASUTO
权利人:KAO CORP; FUJIMURA TSUTOMU; OGAWA AYUMI; OHSU HIROYUKI; TAKEMA YOSHINORI; HORI KIMIHIKO; AMANO SHINYA; FUJIMORI TAKETOSHI; OHASHI YUKIHIRO; SUZUKI YASUTO
摘要:The present invention relates to methods of stimulating collagen synthesis and of smoothing or removing wrinkles, which comprise administering an effective amount of a benzoic acid derivative of formula (1) or a salt thereof, wherein X is -O- or -N(R4)- (R4 is H or the like), R1 is a C¿4-25?-alkyl or C4-25-alkenyl group, R?2¿ is H, OH, or a C¿1-6?-alkoxyl or C1-6-alkanoyloxy group, and R?3 is -OR5¿ or -N(R?6)R7 (R5? is H, or a C1-25-alkyl or C1-25-alkenyl group), and R?6 and R7¿ are individually H, or a C¿1-3?-alkyl or C1-3-alkenyl group, and use of this compound for agents for stimulating synthesis of collagen, and smoothing or removing wrinkles. This compound (1) stimulates collagen synthesis in human dermal fibroblasts and consequently smooths or removes wrinkles caused by aging and/or photoaging.

专利号:US-2011263720-A1
优先权日:2010-03-09
标 题 :Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same
发明人：PAISLEY STEVEN D; LEPREE JASON M; HAWI AMALE; ECKHOFF MICHAEL
权利人:PENWEST PHARMACEUTICALS CO
摘要:The present invention is directed to a method of synthesizing a compound of Formula I: n n n n n n n n n n the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.

专利号:EP-2647639-A1
优先权日:2012-04-06
标题:ß-boration of alkene and alkyne intermediates
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-borated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

专利号:US-11458114-B2
优先权日:2020-05-19
标 题:Methods and compositions for enhancing synthesis secretion and transport of collagen to increase wound strength
发明人：MARTIN ALAIN
权利人:MARTIN ALAIN; NORTH CELL PHARMACEUTICALS INC
摘要:A method for, and medicinal composition for, treatment of mammalian cells for enhancing synthesis, secretion and transport of collagen to increase wound strength, that includes magnesium pyruvate; calcium pyruvate; L proline; citrulline: and a liquid carrier.

专利号:US-5922335-A
优先权日:1995-05-15
标 题:Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
发明人：PTCHELINTSEV DMITRI
权利人:AVON PROD INC
摘要:Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as 'APC compounds') are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.

专利号:US-2009232915-A1
优先权日:2008-03-14
标 题 :Mixtures with a collagen synthesis boosting action
发明人：SCHMAUS GERHARD; FRANKE HELGE; LANGE SABINE
权利人:SYMRISE GMBH & CO KG
摘要:The invention relates to synergistically active, ternary mixtures which boost collagen synthesis and to the uses thereof, in particular for slowing down skin ageing and for wound healing of damaged skin. The invention furthermore relates to the use of the ternary mixtures according to the invention for treating the oral cavity and pharynx, and in particular therein for preventing and slowing down periodontitis, for building up periodontal connective tissue and for preventing and treating infections in the oral cavity and for wound healing in the oral cavity.