CAS: 67-28-7; Nihydrazone
该化合物是一种属于氢化子类别的化学化合物,其特点是存在一个氢化子功能组(R1R2C=NNH2). 这种化合物通常具有在室温下固体等特性,晶体结构可视其具体形式而有所不同.据了解,Nihydrazone在有机合成中的潜在应用,特别是在形成各种衍生物和作为化学反应的中间体方面,它还可能显示生物活动,使其对药用化学感兴趣.该化合物一般在极地溶剂中溶解,其再活性可能受氢化物存在分体的影响.与许多化学物质一样,由于潜在的毒性或再活性,处理硝水区需要适当的安全措施,同时强调了解其在实验室和工业环境中的特性的重要性.
- 英文名称Nihydrazone
- 中文名称尼海屈腙
- IUPAC名称Acetic acid, ((5-nitro-2-furanyl)methylene)hydrazide (9CI)
- 其它别名Aceticacid, (5-nitrofurfurylidene)hydrazide (6CI,7CI,8CI); Acetic acid,[(5-nitro-2-furanyl)methylene]hydrazide (9CI); Hydrazine,1-acetyl-2-(5-nitrofurfurylidene)- (5CI); 2-Furaldehyde, 5-nitro-,acetylhydrazone (6CI); 1-Acetyl-2-(5-nitro-2-furfurylidene)hydrazide; 5-Nitro-2-furaldehyde acetylhydrazone; 5-Nitrofurfural acetylhydrazone; 5-Nitrofurfurylidene acetylhydrazone; Furiton; NF 64; Nidrafur; Nidrafur P; Nifurhydrazonum; Nihydrazon; Nihydrazone; N'-(5-Nitrofurfurylidene)acethydrazide; Zonifur
- CAS编号67-28-7
- MFCD编号:MFCD00864963
- EINECS号:200-648-6
- FDA UNII编号:8BS3E41XVP
- 分子式:C7H7N3O4分子量:197.15
- 产品CID: 1655180
- 产品分类化学试剂 → 有机试剂 → 腙
物理性质
MSDS等安全信息
上下游产品
CAS号698-63-5 5-硝基糠醛 | CAS号1068-57-1 乙酰肼 | CAS号64-19-7 冰醋酸合成工艺路线路线简述
- 合成目标产物 Nihydrazone 主要起始原料 5-Nitrofurfural And Acethydrazide
- (文献来源)合成步骤主要原料 5-Nitrofurfural 和 Acethydrazide
📜5-硝基糠醛,乙酰肼 以 乙醇 作为反应溶剂,以78%的收率获得产物尼海屈腙
参考文献:Designing And Exploring Active N'-[(5-Nitrofuran-2-yl) Methylene] Substituted Hydrazides Against Three Trypanosoma Cruzi Strains More Prevalent In Chagas Disease Patients
标题:Designing And Exploring Active N'-[(5-Nitrofuran-2-yl) Methylene] Substituted Hydrazides Against Three Trypanosoma Cruzi Strains More Prevalent In Chagas Disease Patients
摘要:Chagas Disease Affects Around 8 Million People Worldwide And Its Treatment Depends On Only Two Nitroheterocyclic Drugs,Benznidazole (Bzd) And Nifurtimox (Nfx). Both Drugs Have Limited Curative Power In Chronic Phase Of Disease. Nifuroxazide (Nf),A Nitroheterocyclic Drug,Was Used As Lead To Design A Set Of Twenty One Compounds In Order To Improve The Anti-Trypanosoma Cruzi Activity. Lipinski'S Rules Were Considered In Order To Support Drug-Likeness Designing. The Set Of N'-[(5-Nitrofuran-2-yl) Methylene] Substituted Hydrazides Was Assayed Against Three T. Cruzi Strains,Which Represent The Discrete Typing Units More Prevalent In Human Patients: Y (Tcii),Silvio X10 Cl1 (Tci),And Bug 2149 Cl10 (Tcv). All The Derivatives,Except One,Showed Enhanced Trypanocidal Activity Against The Three Strains As Compared To Bzd. In The Y Strain 62% Of The Compounds Were More Active Than Nfx. The Most Active Compound Was N'((5-Nitrofuran-2-yl) Methylene)Biphenyl-4-Carbohydrazide (C20),Which Showed Ic50 Values Of 1.17 +/-0.12 Mu M; 3.17 +/-0.32 Mu M; And 1.81 +/-0.18 Mu M For Y,Silvio X10 Cl1,And Bug 2149 Cl10 Strains,Respectively. Cytotoxicity Assays With Human Fibroblast Cells Have Demonstrated High Selectivity Indices For Several Compounds. Exploratory Data Analysis Indicated That Primarily Topological,Steric/geometric,And Electronic Properties Have Contributed To The Discrimination Of The Set Of Investigated Compounds. The Findings Can Be Helpful To Drive The Designing,And Subsequently,The Synthesis Of Additional Promising Drugs Against Chagas Disease. (C) 2015 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2015.03.066
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2904209090-其他仅含硝基或亚硝基衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Lott RL. Nitrofuran Production Efficiency In Chickens. Can J Comp Med Vet Sci. 1962 Feb;26(2):36-8.
2: BOONE MA, BARNETT BD. THE EFFECT OF NIDROXYZONE AND NIHYDRAZONE ON LAYING HENS. Poult Sci. 1965 Mar;44:514-9. doi: 10.3382/ps.0440514.
44:578-82. doi: 10.3382/ps.0440578. 59(5):1027-30. doi: 10.3382/ps.0591027.
合成参考文献
参考文献:10.1007/s11172-025-4801-5
摘要:Dudarev VG, Vasendin MI, Tikhomirova OM. Synthesis and antibacterial activity of hybrid structures based on 5-nitrofurfural acetylhydrazone and 3,5-dichlorosalicylanilides. Russ Chem Bull. 2025 Oct;74(10):3211–7. doi: 10.1007/s11172-025-4801-5.
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