CAS: 62666-20-0; Progabide
- 英文名称Progabide
- 中文名称普罗加比
- IUPAC名称(Z)-4-(((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene)amino)butanamide
- 其它别名4-[[(Z)-(4-Chlorophenyl)-(3-Fluoro-6-Oxocyclohexa-2,4-Dien-1-Ylidene)Methyl]Amino]Butanamide; Progabide, (Z)-; 4-[[(Z)-(4-Chlorophenyl)-(3-Fluoro-6-Oxo-Cyclohexa-2,4-Dien-1-Ylidene)Methyl]Amino]Butanamide; Progabide; Progabidum; Schembl3
- CAS编号62666-20-0
- MFCD编号:MFCD01740869
- EINECS号:263-679-4
- 分子式:C17H16ClFN2O2分子量:334.78
- 产品CID: 1608022
- 产品分类原料药 → 神经系统用药 → 抗癫痫及抗惊厥药
物理性质
- 熔点133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
- 沸点525.363 °C at 760 mmHg
- 闪点271.53 °C
- 密度1.3g/cm3
- pKa:pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
- PSA:75.68
- LogP:3.9879
- 折射率1.59
- 蒸汽压0 mmHg at 25 °C
- 溶解性Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)
- 外观形态淡黄色至黄色固体
- 储存条件2-8°C
- 产品应用该化合物用作治疗癫痫(特别是部分缉获)和粘性的一种GABA(伽马-氨基丁酸)受体激动剂.
上下游产品
CAS号62665-97-8 4-[[(Z)-(4-chlo... | CAS号62433-26-5 4'-氯-5-氟-2-羟基二苯甲酮合成工艺路线路线简述
📜4-[(4-Chlorophenyl)-(5-Fluoro-2-Hydroxyphenyl)Methylidene]Azaniumylbutanoate 反应生成 普罗加比
参考文献:De2634288
标题:De2634288
海关参考信息
- 2902300000-甲苯
2903919090-氯苯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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📌 第三方产品分析报告
主要参考文献
1: Tak H, Anirudh J, Chattopadhyay A, Naick BH. Argonaute protein assisted drug discovery for miRNA-181c-5p and target gene ATM translation repression: a computational approach. Mol Divers. 2024 Jul 18. doi: 10.1007/s11030-024-10855-3. Epub ahead of print.
104:107870. doi: 10.1016/j.compbiolchem.2023.107870. Epub 2023 Apr 14. 22(4):500-511. doi: 10.2174/1871527321666220401115529. 20(8):1519-1553. doi: 10.2174/1570159X19666210803144815.
5: Bellofatto M, De Michele G, Iovino A, Filla A, Santorelli FM. Management of Hereditary Spastic Paraplegia: A Systematic Review of the Literature. Front Neurol. 2019 Jan 22;10:3. doi: 10.3389/fneur.2019.00003.
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