CAS: 5636-83-9; N,N-Dimethyl-2-[3-(1-Pyridin-2-Ylethyl)-1H-Inden-2-Yl]Ethanamine

该化合物是属于烷胺类的抗口炎化合物,主要用于抗肾脏和抗过敏特性,具有选择性的H1受体对立作用,有效减轻与过敏反应有关的症状,如痒痒,鼻炎和泌尿.其分子结构允许快速吸收和开始行动,而其亲脂性会增加组织渗透.Dimethindene表现出一种有利的安全性特征,与第一代抗口炎相比,镇静作用最小.它通常配制为阳性盐,以提高溶性和生物利用率.该化合物在热液和口腔制剂中使用,提供临床应用的多功能,其稳定性和有效性使它在过敏管理中成为一个可靠的选择.

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ECHA物质C&L通报REACH预注册

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    专利信息


    专利号:WO-2023204823-A1
    优先权日:2022-04-23
    标题 :Process for synthesis of lignocellulosic based bioproducts
    发明人:JAIN ARPAN
    权利人:JAIN ARPAN
    摘要:The present invention relates to a process for the synthesis of lignocellulosic-based bioproducts. The process involves the biochemical conversion of lignocellulosic biomass generated through agriculture, non-agriculture, and forest that produces streams of high-value goods including cosmetic ingredients, nutraceuticals, carbon fiber, activated carbon, graphene, low-calorie sugar, bioplastic, cellulose pulp, and nano-cellulose based aerogel. The process comprises; a process stage-1 for removing the phenolic compounds (lignin) from lignocellulosic biomass as well as decreasing the crystallinity of the cellulose using alkaline modified ethyl-hydro-oxides (m-EHOs) extraction, a process stage-2 for removal of the hemicellulose fraction of the holocellulose using mild sulfuric acid extraction, and a process stage-3 for chemically treating cellulose pulp with alkaline modified ethyl-hydro-oxides (m-EHOs) solvent for the production of nano-cellulose and micro-cellulose fractions. Along with the production of high-value goods, the process generates energy.

    专利号:US-7919505-B2
    优先权日:2006-07-11
    标题 :Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
    发明人:TING PAULINE C; LEE JOE F; FENG KUNG-I; REEDER MICHAEL R; TRZASKA SCOTT T; ZHU MAN; MAO CHEN; FILIPOV DIMITAR L; ZARKADAS DIMITRIOS N
    权利人:SCHERING CORP
    摘要:The present invention relates to the compound of the formula n nTo methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.

    专利号:US-2011003780-A1
    优先权日:2007-07-10
    标题:Hydrogen chloride salt of a substituted 5-oxazol-2-yl-quinoline compound and a process for the production thereof
    发明人:ZHU MAN
    权利人:SCHERING CORP
    摘要:The present invention relates to the compound of the Formula I: n n n n n n n n n n and to methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to a particular crystalline form and processes of synthesis of the crystalline form. n IM=105109

    专利号:WO-2023075715-A1
    优先权日:2021-10-26
    标题 :A pharmaceutical formulation including leukotriene receptor antagonists and/or leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (nsaids)
    发明人:OYTUN FARUK; CAN EFE
    权利人:VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI
    摘要:This invention is related to a pharmaceutical formulation including Leukotriene receptor antagonists and/or Leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (NSAIDs) and antihistamines in ocular diseases and in inflammatory and allergic diseases for systemic and topical use. The objective of this invention is to create a novel formulation to be effective as much as steroids while having significantly less side effects for long-term use in treating ocular diseases, inflammatory and allergic diseases. In other words our aim is to achieve the inhibition of pro-inflammatory mediators (prostaglandins, thromboxane, histamine and leukotrienes) as much as steroids do with a safer combination.

    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

    专利号:US-2005053642-A1
    优先权日:2000-08-23
    标题:Biocompatible materials
    发明人:ULBRICHT MATHIAS; THOM VOLKMAR; JANKOVA KATJA; ALTANKOV GEORGE; JONSSON GUNNAR
    摘要:The present invention teaches a novel approach of creating biocmpatible surfaces, said surfaces being capable of functionally interact with biological material. SAid biocompatible surfaces comrise at least two comonents, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, which, in a cooperativity, form together the novel biocoompatible surfaces. The novel approach is ased on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of said hydrophilic and flexible macromolecules, exhibiting a pronounced excluded volume. The htus formed two component surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by: i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecules(s) is in turn determined by synthesis. AMount and conformation and thus also biological activity of biological material (as e.g. polypeptides) which contact the novel biocompatible surface, is determined and maintained by the cooperative action of the underlying hydrophobic substratum and the macromolecular layer. In this way it becomes possible to maintain and control biological interactions between said contacted polypeptides and other biological compounds as e.g. cells, antibodies and the like. Consequently, the present invention aims to reduce and/or eliminate the deactivation and/or denaturation associated with the contacting of polypeptides and/or other biological material to a hydrophobic substratum surface.

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    主要参考文献


    1: Leroy A, Baeck M, Tennstedt D. Contact dermatitis and secondary systemic allergy to dimethindene maleate. Contact Dermatitis. 2011 Mar;64(3):170-1. doi: 10.1111/j.1600-0536.2010.01830.x. doi: 10.1016/j.jpba.2009.03.032. Epub 2009 Apr 5. German. French.

    合成参考文献


    参考文献:10.1016/j.urology.2009.12.013
    摘要:Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor MB, Yoshimura N. Differential Roles of M2 and M3 Muscarinic Receptor Subtypes in Modulation of Bladder Afferent Activity in Rats. Urology. 2010 Apr;75(4):862–7. doi: 10.1016/j.urology.2009.12.013.
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