CAS: 559-70-6; β-Amyrin

该化合物是一种被归类为五环三叶杆的三叶杆化合物,通常存在于各种植物中,特别是Euphorbiaceae家族和一些药草中,其分子分子配方为C30H50O,分子重量约为426.7克/摩尔. -阿美林的特征是其白色晶体外观,因其重要的生物活动而闻名,包括抗炎,抗氧化剂和抗微生物特性.该化合物呈现出一个复杂的结构,多环,有助于其稳定性和与生物系统的互动.它经常被研究其潜在的治疗用途,特别是在传统医学方面.此外, --亚美林可以参与其他重要化合物的生物合成,并因其在植物防御机制中的作用而得到承认.其溶解性一般在水中较低,但可溶解于有机溶剂中,因此适合在植物化学学中采用各种提取方法.

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合成工艺路线路线简述

    📜齐墩果酸置于咪唑,Lithium Aluminium Tetrahydride,Potassium Carbonate,三乙胺,锌体系中,用 四氢呋喃,二氯甲烷,溶剂黄146,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 45.5H,反应生成 β-香树精
    参考文献:改进的可扩展合成α-和β-淀粉状蛋白.
    标题:改进的可扩展合成α-和β-淀粉状蛋白.
    摘要:α-和β-淀粉糊精的合成是从容易获得的起始原料齐墩果酸和熊果酸开始的.该程序允许通过选择性碘化和还原,以极短的可扩展方式制备β-Amyrin.对于α-Amyrin,必须选择不同的合成方法,以提供中到大型的α-Amyrin.
    DOI:10.3390/molecules23071552

    海关参考信息

    专利信息


    专利号:WO-2024108582-A1
    优先权日:2022-11-25
    标题:Recombinant strain, construction method therefor, and use thereof in preparation of quillaic acid
    发明人:CHOU HOWARD H; YANG JIAZENG
    权利人:SHENZHEN INST OF ADV TECH CAS
    摘要:Provided are a recombinant strain, a construction method therefor, and a use thereof in the preparation of quillaic acid. In the recombinant strain, a coding sequence of an msbp protein is inserted, said msbp protein being able to promote cytochrome P450 oxidase in the recombinant bacteria to form a complex, and the yield of quillaic acid with cytochrome P450 oxidase participating in synthesis is increased.

    专利号:US-7135624-B2
    优先权日:2001-03-09
    标题 :Enzymes involved in triterpene synthesis
    发明人:BRYAN GREGORY T; MCGONIGLE BRIAN; MAXWELL CARL A
    权利人:DU PONT
    摘要:This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to a suitable regulatory sequence.

    专利号:US-8614369-B2
    优先权日:2007-06-25
    标 题:Enzymes involved in triterpene synthesis
    发明人:OSBOURN ANNE; QI XIAOQUAN
    权利人:PLANT BIOSCIENCE LTD
    摘要:This invention relates to isolated polynucleotides encoding enzymes consisting of a carboxypeptidase-like protein, a methyltransferase and a glucosyltransferase, involved in the biosynthesis of β-amyrin-derived triterpenes in plants and seeds. The invention also relates to the construction of recombinant DNA constructs comprising all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to at least one regulatory sequence.

    专利号:US-8647875-B2
    优先权日:2004-10-15
    标题 :Enzymes involved in triterpene synthesis
    发明人:OSBOURN ANNE; QI XIAOQUAN
    权利人:OSBOURN ANNE; QI XIAOQUAN; PLANT BIOSCIENCES LTD
    摘要:This invention relates to isolated polynucleotides encoding a CYP51H. The invention also relates to the construction of recombinant DNA constructs comprising all or a portion of the isolated polynucleotide of the invention, in sense or antisense orientation, operably linked to at least one regulatory sequence.

    专利号:US-8257754-B2
    优先权日:2002-10-21
    标 题:Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    专利号:US-8486457-B2
    优先权日:2002-10-21
    标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

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    主要参考文献


    1: Wen S, Gu D, Zeng H. Antitumor effects of beta-amyrin in Hep-G2 liver carcinoma cells are mediated via apoptosis induction, cell cycle disruption and activation of JNK and P38 signalling pathways. J BUON. 2018 Jul-Aug;23(4):965-970. doi: 10.1016/j.phymed.2017.09.002. Epub 2017 Sep 21. doi: 10.1007/s00210-017-1404-1. Epub 2017 Jul 17. doi: 10.1016/j.bbrc.2015.10.085. Epub 2015 Oct 20. doi: 10.3109/13880209.2014.898078. Epub 2014 Jul 15. Epub 2004 Dec 30.

    合成参考文献


    参考文献:10.1371/journal.pone.0021891
    摘要:Dai J, Zong Y, Zhong L, Li Y, Zhang W, Bian L, Ai Q, Liu Y, Sun J, Lu D. Gastrodin Inhibits Expression of Inducible NO Synthase, Cyclooxygenase-2 and Proinflammatory Cytokines in Cultured LPS-Stimulated Microglia via MAPK Pathways. PLoS ONE. 2011 Jul 12;6(7):e21891. doi: 10.1371/journal.pone.0021891.
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