专利号:WO-2024108582-A1 优先权日:2022-11-25 标题:Recombinant strain, construction method therefor, and use thereof in preparation of quillaic acid 发明人:CHOU HOWARD H; YANG JIAZENG 权利人:SHENZHEN INST OF ADV TECH CAS 摘要:Provided are a recombinant strain, a construction method therefor, and a use thereof in the preparation of quillaic acid. In the recombinant strain, a coding sequence of an msbp protein is inserted, said msbp protein being able to promote cytochrome P450 oxidase in the recombinant bacteria to form a complex, and the yield of quillaic acid with cytochrome P450 oxidase participating in synthesis is increased.
专利号:US-7135624-B2 优先权日:2001-03-09 标题 :Enzymes involved in triterpene synthesis 发明人:BRYAN GREGORY T; MCGONIGLE BRIAN; MAXWELL CARL A 权利人:DU PONT 摘要:This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to a suitable regulatory sequence.
专利号:US-8614369-B2 优先权日:2007-06-25 标 题:Enzymes involved in triterpene synthesis 发明人:OSBOURN ANNE; QI XIAOQUAN 权利人:PLANT BIOSCIENCE LTD 摘要:This invention relates to isolated polynucleotides encoding enzymes consisting of a carboxypeptidase-like protein, a methyltransferase and a glucosyltransferase, involved in the biosynthesis of β-amyrin-derived triterpenes in plants and seeds. The invention also relates to the construction of recombinant DNA constructs comprising all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to at least one regulatory sequence.
专利号:US-8647875-B2 优先权日:2004-10-15 标题 :Enzymes involved in triterpene synthesis 发明人:OSBOURN ANNE; QI XIAOQUAN 权利人:OSBOURN ANNE; QI XIAOQUAN; PLANT BIOSCIENCES LTD 摘要:This invention relates to isolated polynucleotides encoding a CYP51H. The invention also relates to the construction of recombinant DNA constructs comprising all or a portion of the isolated polynucleotide of the invention, in sense or antisense orientation, operably linked to at least one regulatory sequence.
专利号:US-8257754-B2 优先权日:2002-10-21 标 题:Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response 发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M 权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M; METAPROTEOMICS LLC 摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
专利号:US-8486457-B2 优先权日:2002-10-21 标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response 发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE 权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC 摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
1: Wen S, Gu D, Zeng H. Antitumor effects of beta-amyrin in Hep-G2 liver carcinoma cells are mediated via apoptosis induction, cell cycle disruption and activation of JNK and P38 signalling pathways. J BUON. 2018 Jul-Aug;23(4):965-970. doi: 10.1016/j.phymed.2017.09.002. Epub 2017 Sep 21. doi: 10.1007/s00210-017-1404-1. Epub 2017 Jul 17. doi: 10.1016/j.bbrc.2015.10.085. Epub 2015 Oct 20. doi: 10.3109/13880209.2014.898078. Epub 2014 Jul 15. Epub 2004 Dec 30.
合成参考文献
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