专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:US-7452701-B2 优先权日:1998-11-24 标 题:Methods for the preparation of β-amino acids 发明人:FREY PERRY A; RUZICKA FRANK J 权利人:WISCONSIN ALUMNI RES FOUND 摘要:Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare β-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure β-amino acids from α-amino acids comprising catalyzing the conversion of an α-amino acid to a corresponding β-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.
专利号:US-8338473-B2 优先权日:2007-02-28 标 题 :Derivatives of psammaplin A, a method for their synthesis and their uses for the prevention or treatment of cancer 发明人:GRONEMEYER HINRICH; ALTUCCI LUCIA; DE LERA ANGEL; STUNNENBERG HENDRIK GERARD 权利人:GRONEMEYER HINRICH; ALTUCCI LUCIA; DE LERA ANGEL; STUNNENBERG HENDRIK GERARD; CENTRE NAT RECH SCIENT; UNIV STRASBOURG; INST NAT SANTE RECH MED; UNIV VITO; SECONDA UNI DEGLI STUDI DI NAPOLI; RADBOUD UNIVERSITY NIJMEGEN 摘要:Derivatives of psammaplin A responding to formula (I), a method for their synthesis and their use for the preparation of a medicament for preventing and for treating a tumor or a cancer. Formula (I).
专利号:US-2023313245-A1 优先权日:2021-11-10 标 题 :Engineered Enzymes and Method for the Synthesis of Diverse Tyrosine Analogs
专利号:WO-2023086520-A2 优先权日:2021-11-10 标 题:Engineered enzymes and method for the synthesis of diverse tyrosine analogs
专利号:EP-1992698-B1 优先权日:2006-02-22 标 题 :METHOD FOR SYNTHESIS OF SUPPRESSOR tRNA, DNA CONSTRUCT, AND PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE DNA CONSTRUCT