CAS: 52663-78-2; Pcb 195

该化合物是一种多氯联苯同族体,其特点是氯化程度很高,该化合物主要用于研究和分析应用,因其持久性和稳定性,使其成为环境和毒理学研究的宝贵参考标准,其明确界定的结构允许精确校准气体色谱和质谱测量,协助在复杂的基质中检测和量化多氯联苯.该化合物的化学惰性及低挥发性确保实验室环境的可靠性能.然而,由于该化合物的环境持久性和潜在生物累积性,其使用受到严格管制,需要按照安全议定书进行谨慎的处理和处置.

英文名称Pcb 195
中文名称2,2',3,3',4,4',5,6-八氯联苯
IUPAC名称1,2,3,4,5-pentachloro-6-(2,3,4-trichlorophenyl)benzene
其它别名2,2',3,3',4,4',5,6-°Ctachlorobiphenyl; 2,3,4,2',3',4',5',6'-°Ctachlorobiphenyl; 2,3,4,5,6,2',3',4'-°Ctachlorobiphenyl
CAS编号52663-78-2
MFCD编号:MFCD00152682
EINECS号:250-646-4
分子式:C12H2Cl8分子量:429.77
产品CID: 2496368
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: JAHJITLFJSDRCG-UHFFFAOYSA-N
1S/C12H2Cl8/c13-4-2-1-3(6(14)7(4)15)5-8(16)10(18)12(20)11(19)9(5)17/h1-2H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,3,4-trichloroaniline pentachlorobenzene 1,2,3-trichloro-4-iodobenzene 2,3,4,5,6-pentachloroiodobenzene

合成工艺路线路线简述

📜1,2,3,4-四氯苯置于盐酸体系中,化学反应 2.0H,反应生成 2,2',3,3',4,4',5,6-八氯联苯
参考文献:氯苯热解反应生成多氯联苯的机理.
标题:氯苯热解反应生成多氯联苯的机理.
摘要:多氯联苯(pcb)是通过在hcl气氛中热解氯苯而形成的.各种取代的氯苯用作模型化合物以优化缩合反应.与较高的氯苯相比,较低的氯苯可生产更多的pcb.通过缩合反应可生产至多0.7 Microg Pcbs / Mg 1,2,3-三氯苯.
DOI:10.1016/s0045-6535(00)00434-3