CAS: 41244-53-5; 2,4-Bis(Benzyloxy)-5-Bromopyrimidine

该化合物是一种有机化合物,其特征是其丙酰胺核心,是含有1和3位置氮原子的六人芳香环,在2和4位置上存在两个苯基氧组,这增强了其溶性和再活动性,使其在各种合成应用中有用.5位置上的溴原子引入了卤素功能,可参与核生殖替代反应,从而扩大其在有机合成中的用途.该化合物在标准条件下一般表现出中等稳定性,但可能对强酸或基体敏感,这可能导致苯基氧组的水解.其分子结构允许生物系统中的潜在互动,使其对医药化学感兴趣.此外,该化合物独特的功能组群组合可能具有特定的电子特性,影响其再活性和与其他分子的相互作用.

结构式图片

相似化合物

205672-19-1 56686-16-9 742058-39-5

物理性质

MSDS等安全信息

上下游产品

CAS号36082-50-5 5-溴-2,4-二氯嘧啶 | CAS号100-51-6 苯甲醇 | CAS号70523-24-9 2,4-二苄氧基嘧啶-5-硼酸 | CAS号128376-62-5 lithium,2,4-bis...

合成工艺路线路线简述

    📜5-溴-2,4-二氯嘧啶置于sodium Hydride体系中,用 甲苯 作为反应溶剂,化学反应 1.0H,以73.3%的收率获得产物5-溴-2,4-二(苯基甲氧基)-嘧啶
    参考文献:Wo2007/125061
    标题:Wo2007/125061

    海关参考信息

    专利信息


    专利号:US-RE37623-E
    优先权日:1993-11-02
    标题:Enzyme inhibitors, their synthesis, and methods for use
    发明人：EL KOUNI MAHMOUD H; NAGUIB FARDOS N M; SCHINAZI RAYMOND F
    权利人:EL KOUNI MAHMOUD H; NAGUIB FARDOS N M; SCHINAZI RAYMOND F
    摘要:Novel compounds are provided that are effective to inhibit the activity of DHUDase or UrdPase. Such compounds have the general formula n where X is S or Se; Y is H, I, F, Cl, Br, methoxy, benzyl, selenenylphenyl, or thiophenyl, and R 1 is H or an acyclo tail having the general formula n where R 2 is H, CH 2 OH or CH 2 NH 2 ; R 3 is OH, NH 2 , or OCOCH 2 CH 2 CO 2 H; and R 4 is O, S, or CH 2 . n The compounds can be used in pharmaceutical compositions, along with various chemotherapeutic agents to increase the efficacy of the treatment. These compounds can also be used in methods of treating patients by coadministering or sequentially administering the enzyme inhibiting compounds with a chemotherapeutic agent effective to treat cancers, or viral, fungal, bacterial, or parasitic infections. The compounds have further utility in enhancing imaging. Further, they can be administered alone to prevent and/or treat disorders of pyrimidine catabolism and other physiological disorders.

    专利号:CN-114940676-B
    优先权日:2022-07-06
    标题:Synthesis method of pseudouridine

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    主要参考文献

    参考标题:Synthesis Of 5-Fluorovinyl Derivatives Of Pyrimidines Via Suzuki-Miyaura Coupling And Their 1,3-Dipolar Cycloaddition Reactions With Nitrones
    作者:Hanna Wójtowicz-Rajchel,Henryk Koroniak |发布日期:2012.3
    摘要:A Simple Two-Step Synthesis Of A New Class Of Fluorinated Isoxazolidinyl Derivatives Of Pyrimidine Is Described. The Reactions Proceed Via The Suzuki-Miyaura Coupling Followed By Highly Regioselective 1,3-Dipolar Cycloaddition With Nitrones. Removal Of The Pyrimidine Protecting Groups Leads To A Fluorinated Isoxazolidine Analogue Of Pseudouridine.

    合成参考文献


    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 363.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 397.
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