CAS: 3874-54-2; 4-Chloro-1-(4-Fluorophenyl)Butan-1-One

上下游产品

CAS号3308-94-9 2-(3-氯丙基)-2-(4-... | CAS号462-06-6 氟苯 | CAS号4635-59-0 4-氯丁酰氯 | CAS号352-13-6 4-氟苯基溴化镁 | CAS号1183278-95-6 1-(4-chlorobut-... | CAS号3308-94-9 2-(3-氯丙基)-2-(4-... | CAS号3575-80-2 美哌隆 | CAS号582-83-2 4-氟苯丁酮 | CAS号1893-33-0 匹泮哌隆 | CAS号212831-73-7 1-(4-fluorophen... | CAS号2560-31-8 1-(4-FLUORO-PHE... | CAS号898767-06-1 5-(4-FLUOROPHEN... | CAS号54540-58-8 1-(4-氯丁基)-4-氟苯 | CAS号772-31-6 4-氟苯基环丙基甲酮 | CAS号7152-03-6 4-甲氧基苯基环丙基甲酮

1-(4-氯丁-1-炔-1-基)-4-氟苯置于水体系中,用 1,4-二氧六环 作为反应溶剂,以85%的收率获得产物4-氯-4'-氟苯丁酮
参考文献:具有酸和氧化还原特性的双金属纳米固体,用于催化活化 C-C 和 C-H 键†
标题:具有酸和氧化还原特性的双金属纳米固体,用于催化活化 C-C 和 C-H 键†
摘要:提出了一种形成具有酸和氧化还原催化特性的自支撑双金属纳米固体的新方法.它们对水,空气和 H 2稳定,并且能够激活要求苛刻的 C-c 和 C-h 反应.对 Ag-Fe 双金属体系形成的详细机理研究表明,Ag +,O 2(空气)和 Fe 2+之间发生快速氧化还原耦合序列,产生由 O 桥联双原子 Fe 3+支撑的单分散 Ag 纳米粒子三氟甲酰亚胺.该系统可以扩展到嵌入 Cu 2+,Bi 3+和 Yb 3+三氟甲酰亚胺基质中的银纳米颗粒.
DOI:10.1039/c6Sc03335K

专利信息

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

专利号:US-4782061-A
优先权日:1984-12-21
标题:Method of treating psychotropic conditions employing substituted piperazine compounds
发明人：KRUSE CORNELIS G; VAN DER HEYDEN JOHANNES A M; VAN WIJNGAARDEN INEKE; HARTOG JAN; OLIVIER BEREND
权利人:DUPHAR INT RES
摘要:The invention relates to a group of new bicyclic heteroarylpiperazine derivatives of formula 1. It was found that these compounds have interesting psychotropic in particular anti-psychotic properties. The compounds can be prepared according to methods known for the synthesis of analogous compounds.

专利号:ES-2776889-T3
优先权日:2007-03-12
标题 :Synthesis of gamma-carbolines fused to substituted heterocycle

专利号:US-5075339-A
优先权日:1989-07-28
标 题:Benzylketone phospholipase A2 inhibitors
发明人：WILKERSON WENDELL W
权利人:DU PONT MERCK PHARMA
摘要:The invention relates to benzylketone phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2-mediated conditions in mammals by administration of a therapeutically effective amount of such a benzylketone phospholipase A2 inhibitor. These compounds are also intermediates in the synthesis of other PLA2 inhibitors.

专利号:US-2003073681-A1
优先权日:2001-08-21
标题:2-substituted piperidines that are ligands for monoamine receptors and transporters
发明人：HAUSKE JAMES R; AQUILA BRIAN M
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.