CAS: 345-83-5; 4-Fluorobenzophenone

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CAS号1765-93-1 4-氟苯硼酸 | CAS号98-88-4 苯甲酰氯 | CAS号93-97-0 苯甲酸酐 | CAS号1227828-27-4 4-(triethoxysil... | CAS号98-80-6 苯硼酸 | CAS号25569-77-1 4-氟苯甲酸酐 | CAS号587-79-1 4-氟二苯基甲烷 | CAS号395-21-1 Benzene,1-fluor... | CAS号65-85-0 苯甲酸 | CAS号403-43-0 对氟苯甲酰氯 | CAS号106947-61-9 phenyl-(4-piper... | CAS号106315-29-1 [4-(4-phenoxyph... | CAS号371-41-5 4-氟苯酚 | CAS号456-22-4 对氟苯甲酸 | CAS号65-85-0 苯甲酸 | CAS号108-95-2 苯酚 | CAS号20953-62-2 [4-(4-benzoylan... | CAS号611-94-9 4-甲氧基二苯甲酮 | CAS号365-21-9 Α-氯-Α-苯基-4-氟甲苯 | CAS号2714-93-4 Phenol, 4-fluor...

4-羟基-二苯甲酮置于硫酰氟,四甲基氟化铵,三乙胺体系中,用 1,4-二氧六环,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 48.0H,反应生成 4-氟二苯甲酮
参考文献:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
标题:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
摘要:本报告描述了一种通过芳基氟磺酸 (Arofs) 中间体使用硫酰氟 (So2F2) 和四甲基氟化铵 (Nme4F) 对苯酚进行脱氧氟化的方法.我们首先证明 Arofs 与 Nme4F 的反应在温和条件下(通常在室温下)进行,以提供广泛的电子多样化和富含官能团的芳基氟化物产品.然后将该转化转化为使用 So2F2 和 Nme4F 的组合将苯酚一锅法转化为芳基氟化物.从头算计算表明,碳-氟键的形成是通过协调的过渡态而不是离散的迈森海默中间体进行的.
DOI:10.1021/jacs.6B12911

专利信息

专利号:US-10865390-B2
优先权日:2018-02-12
标 题 :Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-10822593-B2
优先权日:2018-02-12
标 题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-11078465-B2
优先权日:2018-02-12
标题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; WANG YUE; DAI WEI; XU GUOCHAO; ZHOU JIEYU
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-9035013-B2
优先权日:2010-08-04
标 题 :Sulphur-containing triazine monomer that can be used for the synthesis of a polymer membrane for a fuel cell
发明人：FEDURCO MILAN
权利人:FEDURCO MILAN; MICHELIN & CIE; MICHELIN RECH TECH
摘要:A sulphur-containing triazine monomer is provided that can be used in the synthesis of a polymer membrane for a PEM-type fuel cell. The sulphur-containing triazine monomer has a structure corresponding to a formula (I): n nin which:n Tz represents a 1,3,5-triazine nucleus; X 1 and X 2 , which are identical or different, represent S, SO, or SO 2 ; Ar 1 , Ar 2 , Ar 4 and Ar 5 , which are identical or different, represent a substituted or unsubstituted phenylene group; Ar 3 represents a substituted or unsubstituted phenyl group; and Z 1 and Z 2 , which are identical or different, are selected from a group that includes halogens, hydroxyl, alkoxyl, thiol, carboxyl, carboxylates, amine, sulphonamide, acyl chlorides, sulphonyl chlorides, sulphonyl fluorides, isocyanates, and combinations thereof.

专利号:US-4453012-A
优先权日:1982-04-22
标 题 :Process for the preparation of phenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

专利号:US-4454350-A
优先权日:1982-01-21
标题:Process for the acylation of halo- or trihalomethylbenzenes
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the acylation of halo- or trihalomethylbenzenes, wherein a halo- or trihalomethylbenzene is reacted with a carboxylic acid, a precursor or a derivative thereof in the presence of boron trifluoride in an amount such that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having a phytosanitary (e.g., herbicidal) or pharmaceutical activity.