CAS: 3098-92-8; Vinyl 3-Phenylacrylate

上下游产品

(vinyl)trimethoxylsilane Cinnamic acid vinyl acetatebenzy cinnamate acetaldehyde (3R)-1-hepten-3-ol ethyl 3-phenyl-2-propenoate

📜乙酸乙烯酯,肉桂酸置于lithium Acetate,Copper(Ll) Bromide,Palladium Dichloride体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 肉桂酸乙烯酯
参考文献:发现酰化异槲皮苷衍生物作为体外和体内有效的抗神经炎症剂
标题:发现酰化异槲皮苷衍生物作为体外和体内有效的抗神经炎症剂
摘要:神经炎症被认为是神经退行性疾病的重要病理机制.据报道,天然异槲皮苷 (Iq) 具有潜在的抗神经炎症活性.iq中糖苷的酰化增强了其疏水性,有望增强抗炎症的保护作用.本研究通过相应的乙烯基酯中间体将肉桂酸,布洛芬(ibu)和乙酰水杨酸等三种具有抗神经炎症作用的羧酸引入到iq的6''-Oh上(8A-8C).最终,使用固定化脂肪酶 Novozym 435 作为催化剂,获得了酰化 Iq 衍生物(化合物9A-9C),产率为 35-42%.随后,在脂多糖(lps)诱导的 Bv2 细胞中评估了它们的抗神经炎症活性.化合物9B在<=50μm范围内改善细胞活力,并以浓度依赖性方式显着降低no,Pge 2 的产生以及tnf-α,Il-1β的释放和氧化应激水平.此外,它还可以下调 Inos,Cox-2,Tnf-α 和 Il-1β 的表达水平,当使用15μm 化合物9B时,可降低约 40% .此外,化合物9B还能
DOI:10.1016/j.Cbi.2023.110675

专利信息

专利号:EP-2647639-A1
优先权日:2012-04-06
标题:ß-boration of alkene and alkyne intermediates
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-borated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

专利号:EP-2647640-A1
优先权日:2012-04-06
标 题:ß-boration of alkene and alkyne intermediates
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-boated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

专利号:US-7294732-B2
优先权日:2002-08-07
标 题:Silicon compound
发明人：OHNO KOHJI; TSUJII YOSHINOBU; FUKUDA TAKESHI
权利人:CHISSO CORP
摘要:A silicon compound represented by Formula (1). In Formula (1), R 1 is a group independently selected respectively from the group consisting of a hydrogen atom, alkyl, substituted or non-substituted aryl and substituted or non-substituted arylalkyl, and A 1 is an organic group substituted with a halogenated sulfonyl group and is preferably a group represented by Formula (2). In Formula (2), X is halogen; R 2 is alkyl; a is an integer of 0 to 2; and Z 1 is a single bond or alkylene having a carbon number of 1 to 10. n n n n n n n n n n The silicon compound provided by the present invention is a silsesquioxane derivative having an excellent living polymerizable radical polymerization initiating function. For example, it is possible to commence polymerization by allowing an acryl base monomer to coexist to form an acryl base polymer making use of one point of the structure of the silsesquioxane in the present invention as a starting point. Because a halogenated sulfonyl group has a strong electrophilicity, it is possible to synthesize various silsesquioxane derivatives by reacting the silicon compound provided by the present invention with various nucleophilic reagents, and it can actively be used as an intermediate useful for organic synthesis.

专利号:US-8541598-B2
优先权日:2007-08-21
标 题 :Biodegradable solvents for the chemical industry
发明人：GATHERGOOD NICK; MORRISSEY SAIBH; PEGOT BRUCE
权利人:GATHERGOOD NICK; MORRISSEY SAIBH; PEGOT BRUCE; UNIV DUBLIN CITY
摘要:This invention relates to ionic liquid (ILs) solvents for chemical synthesis based on an alkyl-imidazolium cation core containing ionic liquids which have enhanced biodegradability and reduced toxicity relative to existing imidazolium bases ILs such as 1-butyl-3-methylimidazolium (bmmim) salts. Many of the described ILs produce a score of over 60% biodegradability over 28 days in a biodegradability test such as the Sturm Test, the Closed Bottle Test (OECD 301D) or the CO 2 Headspace Test (ISO 14593). The ILs of the invention comprise an alkyl substituted imidazolium cationic core having a —Câ•?OX— side chain in the 3-position of the imidazole ring, wherein Xâ•?O, NH, N or S and an associated counteranion characterized in that the —Câ•?OX side chain comprises at least one ether linkage. The biodegradable and non-toxic IL may be used as green solvents for the chemical, pharmaceutical, biofuel and biomass industries. The ILs of the invention are particularly useful in hydrogenation, pericyclic ad metathesis reactions.

专利号:CN-104496813-A
优先权日:2014-12-02
标题 :A kind of cinnamic acid acylglyceride antioxidant and its synthesis method