专利号:WO-0134561-A1 优先权日:1999-11-06 标 题:Processes for the preparation of sumatriptan and related compounds 发明人:HOLMAN NICHOLAS JOHN; FRIEND CHRISTOPHER LYNDON 权利人:KNOLL AG; HOLMAN NICHOLAS JOHN; FRIEND CHRISTOPHER LYNDON 摘要:The present invention relates to a process for preparing phenylhydrazines of formula (I) in which R represents CH2SO2NHCH3, CH2CH2SO2Ph, CH2CH2SO2NHMe or a group of structure (A), (B), (C), in which a diazonium salt of formula (II) in which X represents an anion derived from hydrochloric acid, sulphuric acid, acetic acid, phosphoric acid, tetrafluoroboric acid or hydrobromic acid is reduced by a dithionite salt. The resulting phenylhydrazines can be converted to the corresponding indole derivatives by the Fischer indole synthesis.
专利号:CN-115353492-A 优先权日:2022-08-26 标 题:A method for continuous synthesis of 1-(4-hydrazinophenyl)methyl-1,2,4-triazole
专利号:RU-2110517-C1 优先权日:1990-06-07 标题:N,n-dimethyl-2-(5-(2-oxo-1,3-oxazolidine-4-yl-methyl)-1h-indo- -le-3-yl)-ethylamine, its physiologically acceptable salt or solvate, method of its synthesis, drug used as an agonist of '5-ht1-like' receptor in mammals, method of drug agent preparing
专利号:CN-101962327-A 优先权日:2010-08-30 标 题 :Novel synthesis process of 4- (N, N-dimethylamino) -butyraldehyde dimethyl acetal
专利号:CN-115417859-B 优先权日:2022-09-19 标 题:Synthesis method of rizatriptan benzoate
参考标题:The Asymmetric Synthesis Of Amines Via Nickel-Catalyzed Enantioconvergent Substitution Reactions 作者:Ze-Peng Yang,Dylan J. Freas,Gregory C. Fu |发布日期:2021.2.24 摘要:Dialkyl Carbinamines Do Not Provide General Access To Amines Wherein The Two Alkyl Groups Are Of Similar Size (E.G., Ch2R Versus Ch2R1). Herein, We Report Two Mild Methods For The Catalytic Enantioconvergent Synthesis Of Protected Dialkyl Carbinamines, Both Of Which Use A Chiral Nickel Catalyst To Couple An Alkylzinc Reagent (1.1-1.2 Equiv) With A Racemic Partner, Specifically, An α-Phthalimido Alkyl Chloride
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 29.