CAS: 281655-61-6; (2S)-2-([(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino)-3-(Quinolin-3-yl)Propanoic Acid

相似化合物

1106706-63-1 1108622-91-8 135101-20-1

上下游产品

9-芴甲基-N-琥珀酰亚胺基碳酸酯 N-(9H-Fluoren-2-Ylmethoxycarbonyloxy)Succinimide 82911-69-1

📜3-喹啉甲醛置于盐酸,(R)-[rh(Cod)(Maxphos)]Bf4,氢气,Sodium Carbonate,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 1,4-二氧六环,甲醇,二氯甲烷,水 用作溶剂,100.0 °C,1.5 Mpa 条件下,反应 81.5H,反应生成(2S)-2-([(9H-芴-9-基甲氧基)羰基]氨基)-3-(喹啉-3-基)丙酸
参考文献:Sstr1-And Sstr3-Selective Somatostatin Analogues
标题:Sstr1-And Sstr3-Selective Somatostatin Analogues
摘要:Abstractwe Prepared The Two Enantiomers Of 3‐(3'‐quinolyl)‐alanine (Qla,1) In Multigram Scale By Asymmetric Hydrogenation. These Amino Acids,Protected As Fmoc Derivatives,Were Then Used In The Solid‐phase Synthesis Of Two New Somatostatin 14 (Srif‐14) Analogues 8 A And 8 B,Tetradecapeptides In Which The Tryptophan Residue (Trp8) Is Replaced By One Of The Two Enantiomers Of 3‐(3'‐quinolyl)‐alanine (Qla8) And Therefore Lack The Nh Bond In Residue 8. The Selectivity Of These New Analogues For The Somatostatin Receptors,Sstr1-5,Was Measured. Substitution With L‐qla8 Yielded Peptide 8 A,Which Was Highly Selective For Sstr1 And Sstr3,With An Affinity Similar To That Of Srif‐14. Substitution By D‐qla Gave The Relatively Selective Analogue 8 B,Which Showed High Affinity For Sstr3 And Significant Affinity For Sstr1,Sstr2 And Sstr5. The Biological Results Demonstrate That Bulky And Electronically Poor Aromatic Amino Acids At Position 8 Are Compatible With Strong Activity With Sstr1 And Sstr3. Remarkably,These High Affinity Levels Were Achieved With Peptides In Which The Conformational Mobility Was Increased With Respect To That Of Srif‐14. This Observation Suggests That Conformational Rigidity Is Not Required,And Might Be Detrimental To The Interaction With Receptors Sstr1 And Sstr3. The Absence Of An Indole N Proton In Qla8 Might Also Contribute To The Increased Flexibility Observed In These Analogues.
Doi:10.1002/cbic.201000597