CAS: 27591-42-0; Oxazidione
该化合物是一种属于七环化合物类别的化学化合物,其特点是五人环状结构,含有氮和氧原子,有助于其独特的化学特性.一般而言,氧化氮二烯在标准条件下具有稳定性,尽管在特定情况下,特别是在强酸或基底存在的情况下,它们可能表现出反应性.这些化合物往往表现出有趣的生物活动,使其在各个领域,包括制药和农用化学物中具有兴趣.氧化氮环的存在会影响化合物的溶性,熔点和再活性,而这些是其应用所必需的.此外,氧化氮可参与各种化学反应,例如核分裂代金或循环,取决于其亚种.
- 英文名称Oxazidione
- 中文名称奥沙二酮
- IUPAC名称2-(morpholinomethyl)-2-phenyl-1H-indene-1,3(2H)-dione
- 其它别名Oxazidione; 2-(Morpholinomethyl)-2-Phenyl-1,3-Indanedione; Amplidionne; Mofedione; Transidione; 1H-Indene-1,3(2H)-Dione, 2-(4-Morpholinylmethyl)-2-Phenyl-; Amplidione
- CAS编号27591-42-0
- MFCD编号:MFCD00865270
- EINECS号:248-550-2
- FDA UNII编号:OPC1BN901Y
- 分子式:C20H19NO3分子量:321.38
- 产品CID: 1256270
- 产品分类有机原料 → 苯类化合物 → 茚满类
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2909110000-乙醚
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专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
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主要参考文献
1: Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. doi: 10.1124/mol.115.098368. Epub 2015 Jul 14.
2: Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459.
3: Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11;54(15):5468-77. doi: 10.1021/jm200505e. Epub 2011 Jul 12.
合成参考文献
摘要:Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals, 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989, 11(1096), 1989
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