CAS: 16854-67-4; 4-Hydroxy-2H-Thiochromen-2-One

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📜S-(2-Acetylphenyl) Dimethylthiocarbamate置于sodium Hydride体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 18.0H,以43%的收率获得4-羟基硫代香豆素
参考文献:Novel Cyclization Of S-(O-Acetylaryl) Dimethylthiocarbamates. A New Synthesis Of 3-Hydroxybenzothiophenes And 2-Hydroxythiochromones
标题:Novel Cyclization Of S-(O-Acetylaryl) Dimethylthiocarbamates. A New Synthesis Of 3-Hydroxybenzothiophenes And 2-Hydroxythiochromones
摘要:
Doi:10.1021/jo00385A005

专利信息

专利号:WO-03050105-A2
优先权日:2001-12-10
标题 :Catalytic asymmetric synthesis of optically active compounds
发明人：HALLAND NIS; JOERGENSEN KARL ANKER; HANSEN TORE
权利人:CHEMINOVA AS; HALLAND NIS; JOERGENSEN KARL ANKER; HANSEN TORE
摘要:A one step catalytic asymmetric process for the synthesis of an optically active compound of formula la or lb wherein R is selected from C1-7 alkyl, C1-7 haloalkyl, C1-7 alkoxy, C1-7 haloalkoxy, halogen and hydroxy; R3 is H or C1-4 alkyl; R4 is selected from H, C1-7 alkyl, C1-7 haloalkyl, C1-7 alkoxy, COOH, CO-C1-7 alkoxy and an optionally substituted aryl or heterocycle; AR represents C1-7 alkyl, optionally substituted aryl, an optionally substituted heterocycle or AR and R4 may be bridged together forming part of a ring system; X is O or S; m is a number between 0-4; comprising the step of reacting a compound of the formula 2 with a compound of formula 3 in the presence of a catalytic amount of a chiral nitrogen containing organic compound.