CAS: 153168-05-9; 3-(3,5-Dimethyl-4-(3-(3-Methylisoxazol-5-yl)Propoxy)Phenyl)-5-(Trifluoromethyl)-1,2,4-Oxadiazole

上下游产品

2-(2,2,2-trifluoroethylidene)-1,3-dithiane oxy>benzenecarboxamide imineN-hydroxy-3,5-dimethyl-4-3-(3-methyl-5-isoxazolyl)propyloxybenzenecarboxamide imine trifluoroacetic anhydride

N-Hydroxy-3,5-Dimethyl-4-<<3-(3-Methyl-5-Isoxazolyl)Propyl>Oxy>Benzenecarboxamide Imine 反应生成普可那利
参考文献:1,2,4-Oxadiazolyl-Phenoxyalkylisoxazoles And Their Use As Antiviral
标题:1,2,4-Oxadiazolyl-Phenoxyalkylisoxazoles And Their Use As Antiviral
摘要:式为##str1##的化合物,其中:R.Sub.1是烷基,烷氧基,羟基,环烷基,羟基烷基,烷氧基烷基或羟基烷氧基;Y是3至9个碳原子的脂肪基;R.Sub.2和r.Sub.3独立地是氢,烷基,烷氧基,卤素,三氟甲基和硝基;R.Sub.4是烷氧基,羟基,卤代甲基,二卤代甲基,三卤代甲基,环烷基,烷氧羰基,羟基烷基,烷氧基烷基,烷基羧酸酯氧基烷基,氰基,2,2,2-三氟乙基,(4-甲基苯基)磺酰氧甲基,N.Dbd.Q或con.Dbd.Q,其中n.Dbd.Q是氨基,烷基氨基或二烷基氨基;或其药学上可接受的酸加成盐可用作抗病毒剂.

专利信息

专利号:US-2016185745-A1
优先权日:2013-08-07
标题:Analogs of vinaxanthone and xanthofulvin, methods of synthesis, and methods of treatments thereof
发明人：SIEGEL DIONICIO; CHIN MATTHEW; ELIASEN ANDERS; AXELROD ABRAM
权利人:UNIV TEXAS
摘要:The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.

专利号:WO-9964032-A1
优先权日:1998-06-08
标题 :Combinatorial synthesis of multibinding libraries
发明人：CHRISTENSEN BURTON G; GRIFFIN JOHN H; JENKINS THOMAS E; JUDICE J KEVIN
权利人:ADVANCED MEDICINE INC; CHRISTENSEN BURTON G; GRIFFIN JOHN H; JENKINS THOMAS E; JUDICE J KEVIN
摘要:Disclosed are methods for synthesizing large collections of diverse multimeric compounds as well as iterative processes for evaluating key molecular constraints imparting multibinding properties to multimeric compounds. Also disclosed are libraries of multimeric compounds which can be evaluated for imparting multibinding properties.

专利号:WO-2016202721-A1
优先权日:2015-06-16
标 题:Salts of (s)-4-[(r)-6-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-3,6- dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid, salt former and methods for preparing and using the same
发明人：EGLI ANDRé; DIODONE RALPH; WUITSCHIK GEORG
权利人:HOFFMANN LA ROCHE; HOFFMANN LA ROCHE
摘要:The present invention relates to salts of (S)-4-[(R)-6-(2-Chloro-4-fluoro-phenyl)-5- methoxycarbonyl-2-thiazol-2-yl-3,6-dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid and an acid, the synthesis of the acid salts, and their use for the treatment of pathological disorders, particularly hepatitis B (HBV) infection.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-10736911-B2
优先权日:2015-12-29
标题 :Use of a DHODH inhibitor in combination with an inhibitor of pyrimidine salvage
发明人：DEANS RICHARD; OKESLI AYSE; MORGENS DAVID; KHOSLA CHAITAN; BASSIK MICHAEL C
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compounds and methods are provided for the treatment of pathogenic virus infections or cancer. The formulations combine an inhibitor of de novo pyrimidine synthesis, and an inhibitor of a pyrimidine salvage pathway enzyme.

专利号:US-10065924-B2
优先权日:2014-07-22
标 题 :Preparation and biological evaluation of viridicatumtoxin analogs
发明人：NICOLAOU KYRIACOS C; HALE CHRISTOPHER R H; NILEWSKI CHRISTIAN; IOANNIDOU HERAKLIDIA; EL MARROUNI ABDELLATIF
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.