CAS: 147-55-7; Phenethicillin

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CAS号551-16-6 6-氨基青霉烷酸 | CAS号122-35-0 2-苯氧基丙酰氯

📜6-氨基青霉烷酸,2-苯氧基丙酰氯置于sodium Carbonate体系中,用 丙酮 用作溶剂,化学反应生成非奈西林
参考文献:Derivatives Of 6-Aminopenicillanic Acid. I. Partially Synthetic Penicillins Prepared From α-Aryloxyalkanoic Acids
标题:Derivatives Of 6-Aminopenicillanic Acid. I. Partially Synthetic Penicillins Prepared From α-Aryloxyalkanoic Acids
摘要:
Doi:10.1021/ja01500A036

专利信息

专利号:WO-2025008139-A1
优先权日:2023-07-06
标题 :Process for the continuous synthesis of polyoxazolines using a spiral tube reactor
发明人：WEGENER ERIK; JORDAN RAINER; KIRCHHOF LISA; THOMAS ANITA
权利人:UNIV DRESDEN TECH
摘要:The invention relates to the continuous synthesis of polyoxazolines. The invention also relates to a process for the continuous synthesis of polyoxazolines comprising the step of: conducting at least one oxazoline monomer through a spiral tube reactor under the influence of heat, the spiral tube reactor comprising a helically-wound tube having a tube inner diameter and a diameter of the helical winding, characterised in that: • the tube inner diameter is 4.5 mm to 34 mm and the lambda ratio, as the ratio of the tube inner diameter to the diameter of the helical winding, is in the range of 0.11-0.17, and • the helically-wound tube is a stainless steel tube. The invention also relates to the use of a spiral tube reactor for the continuous synthesis of polyoxazolines, the spiral tube reactor comprising: a helically-wound tube having a tube inner diameter and a diameter of the helical winding, characterised in that: • the tube inner diameter is 4.5 mm to 34 mm and the lambda ratio, as the ratio of the tube inner diameter to the diameter of the helical winding, is in the range of 0.11-0.17, and • the helically-wound tube is a stainless steel tube.

专利号:WO-2013087821-A1
优先权日:2011-12-15
标题:Overproduction of jasmonates in transgenic plants
发明人：CHAMPION ANTONY
权利人:INST RECH DEVELOPPEMENT IRD
摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.

专利号:US-5662898-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances
发明人：LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
权利人:CIBA GEIGY CORP
摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.