CAS: 1446261-44-4; (R)-2-Fluoro-10A-Methyl-5,8,9,10,10A,11-Hexahydro-5,6,7A,11-Tetraazacyclohepta[def]Cyclopenta[a]Fluoren-4(7H)-One

专利信息

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:WO-2022148811-A1
优先权日:2021-01-08
标 题 :Pharmaceutical composition containing a parp inhibitor and/or a genotoxic substance that intervenes in the synthesis phase (s-phase) of cell replication, combined with an inhibitor of the recq5 signal path
发明人：LÖBRICH MARKUS
权利人:UNIV DARMSTADT TECH
摘要:The present invention relates to new pharmaceutical compositions containing RECQ5 inhibitors for use in the treatment and/or prevention of homologous recombination (HR) proficient tumors and/or ATRX deficient tumors and/or ALT tumors in humans.

专利号:US-10238631-B2
优先权日:2014-06-07
标 题 :Sesquiterpene derivatives and their use in inflammation or cancer treatment
发明人：SHYUR LIE-FEN; LEE KUO-HSIUNG; NAKAGAWA-GOTO KYOKO; FENG JIA-HUA; CHEN JO-YU; LEE WAI-LENG; CHENG YU-TING; HUANG JING-YING
权利人:ACADEMIA SINICA
摘要:A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.

专利号:CN-118878526-A
优先权日:2024-07-26
标题:Olaparib derivative containing o-naphthoquinone structure, synthesis method thereof and application of Olaparib derivative in preparation of anti-triple-negative breast cancer drugs