CAS: 1256388-51-8; Methyl ((S)-1-((S)-6-(5-(9,9-Difluoro-7-(2-((1R,3S,4S)-2-((Methoxycarbonyl)-L-Valyl)-2-Azabicyclo[2.2.1]Heptan-3-yl)-1H-Benzo[d]Imidazol-6-yl)-9H-Fluoren-2-yl)-1H-Imidazol-2-yl)-5-Azaspiro[2.4]Heptan-5-yl)-3-Methyl-1-Oxobutan-2-yl)Carbamate

上下游产品

3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester N-methoxycarbonyl-L-valine 6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester (1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester(1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)carbamicacid methyl ester D-tartrate salt

在 Potassium Phosphate体系中,用 2-甲基-2-丁醇,水 用作溶剂,化学反应 5.0H,以100%的收率获得雷迪帕韦
参考文献:Method Of Preparation For Ledipasvir And Derivative Thereof,And Intermediate Compound For Preparation Of Ledipasvir
标题:Method Of Preparation For Ledipasvir And Derivative Thereof,And Intermediate Compound For Preparation Of Ledipasvir
摘要:提供了制备ledipasvir及其衍生物的方法,以及用于制备ledipasvir的中间化合物.具体而言,提供了制备式1化合物的方法和一系列制备ledipasvir的方法.所述方法简单高效,具有更好的应用前景.

专利信息

专利号:WO-2024110994-A1
优先权日:2022-11-25
标题 :A process for the preparation of ledipasvir
发明人：GANGARAJULA SUDHAKAR; CHENNAM RAMU; KUMARAGURU THENKRISHNAN; BABURAO RODE HARIDAS; MADDI REDDY SRIDHAR; CHADA REDDY RAJI; GHOSH SUBHASH
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
摘要:The present disclosure relates to process for the preparation of Ledipasvir (I) or of its pharmaceutically acceptable salts. The present disclosure also provides novel intermediates (IV–XI) that are used in the synthesis of Ledipasvir. The main strategies of the present invention are late-stage functionalization such as difluorination and cyclopropanation of the key intermediates of Ledipasvir (I). (Formula (I))

专利号:US-11485721-B2
优先权日:2017-11-21
标 题:Method for the metal-free preparation of a biaryl by a photosplicing reaction and their uses
发明人：KLOSS FLORIAN; NEUWIRTH TONI; HAENSCH VEIT; HERTWECK CHRISTIAN
权利人:LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST HKI; LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST
摘要:The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II)→Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

专利号:US-10100075-B2
优先权日:2013-12-23
标 题:Process for the preparation of sofosbuvir
发明人：KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; VAKITI SRINIVAS; TIRUMALARAJU BHAVANISANKAR
权利人:MYLAN LABORATORIES LTD; MYLAN LABORATORIES LTD
摘要:The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of sofosbuvir.

专利号:US-10344009-B2
优先权日:2015-11-03
标题 :Process for the preparation of sofosbuvir
发明人：JAYACHANDRA SURESHBABU; KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; DEV VIKAS CHANDRA; KOTTOLLA SAIPRASAD; RAO POTLA VENKATA SRINIVASA; VAKITI SRINIVAS; MUGGU CHAITANYA; DANDALA SUBRAMANYAM
权利人:MYLAN LABORATORIES LTD
摘要:A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

专利号:WO-2024109736-A1
优先权日:2022-11-21
标题:Compound, pharmaceutical composition containing same, synthesis method therefor and use thereof
发明人：CAO BIN; ZHAO LIYU; TIAN YE; DOU GUOSHENG; LU SIZHU; YANG JUN; XIE DEWEI; CHEN ZHAOQIANG; ZHANG QIHUA; WANG SHAOHUI; CHEN BIN; ZHANG PEIYU
权利人:SHENZHEN ZHONGGE BIOLOGICAL TECH CO LTD
摘要:The present application provides a compound as shown in formula (0), a pharmaceutical composition containing same, a synthesis method therefor and a use thereof. The compound of the present application can significantly reduce the integrated stress response (ISR) of cells and activate the activity of eIF2B, so that the protein in the cells tends to be synthesized normally, providing more possible drugs for ISR pathway-mediated diseases or condition eIF2B-related diseases, and/or diseases related to regulation of the activity or level of eIF2B activity or level, and regulation of the activity or level of the eIF2 pathway or ISR pathway.