专利号:US-2008214827-A1 优先权日:2004-02-03 标 题:Synthesis of Cyanoimino-Benzoimidazoles 发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN 权利人:EURO CELTIQUE SA 摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
专利号:US-7759473-B2 优先权日:2005-02-14 标题:Nucleotide oligomer, nucleotide polymer, method for determining structure of functional substance and method for manufacturing functional substance 发明人:FUJIHARA TSUYOSHI; FUJITA SHOZO 权利人:FUJITSU LTD 摘要:A modified nucleotide n-mer (where n is an integer of 2 or more) is used which comprises a nucleoside unit with a substituent group introduced into the base, wherein the substituent group is bound to the base via a triple bond. Novel nucleotide oligomers, nucleotide polymers, and nucleosides which can be used as raw materials or intermediates in the synthesis of this nucleotide oligomer and nucleotide polymer, as well as novel techniques for structural determination and manufacture of a functional substance having high affinity for a target, are provided.
专利号:US-2011040105-A1 优先权日:2008-04-16 标题 :Processes useful for the synthesis of (r)-1--2-methyl-pyrrolidine 发明人:HUBER CHRISTIAN H; KHULMAN YOUNG MI; TANDEL SAGUN K; JOHANNSEN STEPHEN R; WANG TINGMIN; ANGELL PAUL 权利人:ARENA PHARM INC 摘要:Processes useful for making a pharmaceutically useful compound according to Formula (I), forms of such a compound, and intermediates useful in such processes are described.
专利号:US-6030613-A 优先权日:1995-01-17 标题:Receptor specific transepithelial transport of therapeutics 发明人:BLUMBERG RICHARD S; SIMISTER NEIL E; LENCER WAYNE I 权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS 摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
专利号:US-7749985-B2 优先权日:2006-09-15 标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 发明人:GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE 权利人:XENOPORT INC 摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.
专利号:US-4355165-A 优先权日:1978-07-24 标题 :Amino-functionalized phthalhydrazide intermediates 发明人:BOGUSLASKI ROBERT C; CARRICO ROBERT J; CHRISTNER JAMES E 权利人:MILES LAB 摘要:Amino-functionalized phthalhydrazide intermediates of the formula: ##STR1## wherein one of R 5 and R 6 is hydrogen and the other is --NR 7 R 8 ; R 7 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R 8 is ##STR2## wherein n=1-3. The compounds are intermediates in the synthesis of chemiluminescent-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.
1: Nida A, Alston J, Schweinfurth J. Primidone Therapy for Essential Vocal Tremor. JAMA Otolaryngol Head Neck Surg. 2016 Feb 1;142(2):117-21. doi: 10.1001/jamaoto.2015.2849. doi: 10.1097/WNF.0000000000000127. 3: Celik S, Kecel-Gunduz S, Ozel AE, Akyuz S. Structural and vibrational study of primidone based on monomer and dimer calculations. J Biomol Struct Dyn. 2015;33(4):911-23. doi: 10.1080/07391102.2014.913505. Epub 2014 May 7. doi: 10.1016/j.jhazmat.2014.04.028. Epub 2014 Apr 21. doi: 10.1007/s00415-013-7109-6. Epub 2013 Sep 24. doi: 10.1016/j.saa.2013.03.025. Epub 2013 Mar 14. doi: 10.1097/FTD.0b013e3182843206. Review. doi: 10.1016/j.jchromb.2013.02.026. Epub 2013 Feb 27. doi: 10.1097/WNF.0b013e31826249bb. doi: 10.2515/therapie/2012036. Epub 2012 Nov 1. French. doi: 10.1016/j.talanta.2009.04.046. Epub 2009 May 3. doi: 10.1016/j.pbb.2009.05.006. Epub 2009 May 15. Review. Dutch.
合成参考文献
参考文献:10.2147/dhps.s13070 摘要:Mula M, Hesdorffer DC. Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence. Drug Healthc Patient Saf. 2011;3():15–20. 参考文献:10.4061/2011/973692 摘要:Bucossi S, Mariani S, Ventriglia M, Polimanti R, Gennarelli M, Bonvicini C, Pasqualetti P, Scrascia F, Migliore S, Vernieri F, Rossini PM, Squitti R. Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer′s Disease. International Journal of Alzheimer's Disease. 2011 Jan;2011(1). doi: 10.4061/2011/973692. 参考文献:10.1001/jama.1970.03170260058019 摘要:Booker HE. Myasthenia Gravis Syndrome Associated With Trimethadione. JAMA. 1970 Jun 29;212(13):2262. doi: 10.1001/jama.1970.03170260058019.