CAS: 123053-23-6; 4-Chloro-L-Phenylalanine Hydrochloride

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14173-39-8 14091-08-8 142994-19-2

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1-Chloro-4-(chloromethyl)benzene 2-acetylaminomalonic acid diethyl ester 2-acetylamino-2-(4-chlorobenzyl)malonic acid diethyl ester ethyl 2-acetylamino-3-(4-chlorophenyl)-2-cyanopropanoate D-p-chlorophenylalanine methyl ester methyl 2-acetylamino-3-(4-chlorophenyl)propanoate butyl 2-acetylamino-3-(4-chlorophenyl)propanoate allyl 2-acetylamino-3-(4-chlorophenyl)propanoate

📜2-Benzoylamino-3-(4-Chlorophenyl)Acrylic Acid置于盐酸,(+)-(S)-Cationic Rhodium Complex Of "Propharos",氢气体系中,用 甲醇 用作溶剂,25.0 °C,100.0 Kpa 条件下,反应 5.0H,反应生成4-氯-L-苯丙氨酸盐酸盐
参考文献:Unusual Amino Acids Iii. Asymmetric Synthesis Of 3-Arylalanines
标题:Unusual Amino Acids Iii. Asymmetric Synthesis Of 3-Arylalanines
摘要:21 (Z)-Alpha-N-Benzoylamino-Beta-Arylacrylic Acids And Their Esters Were Prepared By Known Procedures And Hydrogenated To The Corresponding Optically Active Alpha-Benzoyl-Beta-Arylalanine Derivatives With Optical Yields In The Range Of 82-95% Ee Using The Cationic Rhodium Complex Of ''Propraphos'' As The Chiral Catalyst No Electronical Influences Of The Substituents At The Aryl Moiety On The Enantioselectivity Were Observed But A Sterical One,Proved By X-Ray Crystallographic Analysis And Computer-Aided Modellings. Deacylation Of The Hydrogenated Spezies Produced The Hydrochlorides Of The 3-Arylalanines Attended By A Partial Racemisation In This Case The Hydrogenation Of Urethane Type Protected Dehydroaminoacid Derivatives Seems To Be The Alternative.
Doi:10.1016/s0957-4166(00)86017-6