CAS: 119916-22-2; 3,4,6-Trifluoro-2-Methylbenzoic Acid
该化合物是一种芳烃式的碳酸,其特点是存在一种以三种氟原子和一组甲基替代的苯酸核心,而苯环的3,4和6个位置是氟酸替代成分,对化合物的化学特性,包括其酸性和极度有重大影响.这种化合物一般在室内温度下是固体,由于C-F联系强,具有高度的热稳定性.其氟化结构会增加亲脂,并可能影响各种溶剂中的溶液.由于氨酸功能组的存在,酸性特性会使其具有酸性,从而能够参与各种化学反应,包括酯化和恐吓.此外,三氟甲基组可以加强生物活动,从而在制药和农业化学研究中引起兴趣.在处理时,应参考安全数据,因为氟化化合物可能会对健康和环境构成特定风险.
- 英文名称3,4,6-Trifluoro-2-Methylbenzoic Acid
- 中文名称2-甲基-3,4,6-三氟苯甲酸
- IUPAC名称3,4,6-trifluoro-2-methylbenzoic acid
- 其它别名3,4,6-Trifluoro-2-Methylbenzoic Acid; 2,4,5-Trifluoro-6-Methylbenzoic Acid; 2-Methyl-3,4,6-Trifluoro Benzoic Acid; 3-Methyl-2,4,5-Trifluorobenzoyl Chloride; 2,4,5-Trifluoro-3-Methylbenzoyl Chloride; Benzoic Acid, 3,4,6-Trifluoro-2-Methyl-
- CAS编号119916-22-2
- MFCD编号:MFCD06410917
- 分子式:C8H5F3O2分子量:190.12
- 产品CID: 264476
- 产品分类有机原料 → 有机氟化合物 → 氟苯甲酸系列
物理性质
上下游产品
1-bromo-2,4,5-trifluorobenzene 2,4,5-trifluorobenzoic acid 2,4,5-trifluorobenzoyl chloride 1-bromo-2,4,5-trifluoro-6-methyl-3-(trimethylsilyl)benzene 2-methyl-3,4,6-trifluorobenzoyl chloride ethyl (2,4,5-trifluoro-6-methylbenzoyl)acetate ethyl α-(ethoxymethylene)-3,4,6-trifluoro-2-methyl-β-oxobenzenepropanoate 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid合成工艺路线路线简述
📜1-Bromo-2,4,5-Trifluoro-6-Methyl-3-(Trimethylsilyl)Benzene置于正丁基锂,Cesium Fluoride体系中,用 乙腈 用作溶剂,化学反应 0.08H,反应生成2-甲基-3,4,6-三氟苯甲酸
参考文献:5-甲基-4-氧代喹啉羧酸的合成
标题:5-甲基-4-氧代喹啉羧酸的合成
摘要:制备了一系列5-甲基-4-氧代-3-喹啉羧酸,其中八个位置被氟,氯,甲基或氢取代.这些喹诺酮是由衍生自恶唑啉8和16的合适的2-甲基-3,4,6-三氟苯甲酸合成的.恶唑啉部分既是邻位导向基团(在可行的情况下)又是保护基团;三甲基甲硅烷基部分被用来封闭分子中最酸性的位点.
Doi:10.1002/jhet.5570270616
海关参考信息
- 2905110000-甲醇
2906210000-苄醇
2912110000-甲醛
2912210000-苯甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:US-6448443-B1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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