CAS: 118457-14-0; (1S)-1-[(2S)-6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl]-2-[[(2S)-2-[(2R)-6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl]-2-Hydroxyethyl]Amino]Ethanol

上下游产品

nebivolol (R)-2-amino-1-[(S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol (R)-2-[(R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl-4-methylbenzenesulfonate (S)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydr°Chromen-4-onenebivolol hydr°Chloride DL-nebivolol hydr°Chloride α,α'-iminobis(methylene)bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydr°Chloride (R)-1-((R)-6-Fluoro-chroman-2-yl)-2-[(S)-2-((R)-6-fluoro-chroman-2-yl)-2-hydroxy-ethylamino]-ethanol; hydr°Chloride

专利信息

专利号:WO-2013018053-A1
优先权日:2011-08-02
标题 :Process for the preparation of epoxides as intermediates for the synthesis of nebivolol
发明人：CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA
权利人:MENARINI INT OPERATIONS LU SA; CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA
摘要:The present invention relates to a novel process of synthesis of epoxides, 6-fluoro-2- (oxiran-2-yl) chroman (Figure 1), intermediates for the synthesis of nebivolol, depicted in Scheme (1), enabling to obtain the above- mentioned epoxides in a racemic or semichiral form.

专利号:US-10392361-B2
优先权日:2016-01-21
标题:Process for the synthesis of intermediates of Nebivolol
发明人：BARTOLI SANDRA; MANNUCCI SERENA; GRISELLI ALESSIO; STEFANINI ALESSIO
权利人:MENARINI INT OPERATIONS LUXEMBOURG SA
摘要:The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I. n The intermediates thus obtained can be used for the synthesis of Nebivolol.

专利号:US-8785664-B2
优先权日:2010-02-11
标 题 :Process for the preparation of nebivolol
发明人：BARTOLI SANDRA; CIPOLLONE AMALIA; FATTORI DANIELA
权利人:MENARINI INT OPERATIONS LU SA
摘要:The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.

专利号:US-8487122-B2
优先权日:2010-02-11
标题 :Process for the preparation of nebivolol
发明人：BARTOLI SANDRA; CIPOLLONE AMALIA; FATTORI DANIELA
权利人:BARTOLI SANDRA; CIPOLLONE AMALIA; FATTORI DANIELA; MENARINI INT OPERATIONS LU SA
摘要:The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.

专利号:US-2011250454-A1
优先权日:2010-04-09
标 题:Preparation of nebivolol
发明人：HALDAR PRANAB; GOLLA CHINA MALAKONDAIAH; SWAPNA AKULA; KUMAR KARRI VIJAYA; JAWLEKAR SUHAS; TUMMALA ARJUN KUMAR; PATRO DEEPALI; YARRAGUNTLA SESHA REDDY; RAMAKRISHNAN SRIVIDYA; CHIMALA VENKATA RAMANA REDDY
权利人:HALDAR PRANAB; GOLLA CHINA MALAKONDAIAH; SWAPNA AKULA; KUMAR KARRI VIJAYA; JAWLEKAR SUHAS; TUMMALA ARJUN KUMAR; PATRO DEEPALI; YARRAGUNTLA SESHA REDDY; RAMAKRISHNAN SRIVIDYA; CHIMALA VENKATA RAMANA REDDY
摘要:Processes for the synthesis of pharmacologically active 2,2-iminobisethanol derivatives, e.g., 2H-1-benzopyran-2 methanol-α,α′-iminobis(methylene)]bis-[6-fluoro-3,4-dihydro-[2R*[R*[R*(S*)]]]], and their pharmaceutically acceptable salts.

专利号:US-9090922-B2
优先权日:2010-11-30
标题:Process for the preparation of nebivolol
发明人：MAURO SANDRO; FATTORI DANIELA; D ANDREA PIERO; CIPOLLONE AMALIA; D ANDREA ENZO; ERCOLANO CARMELA
权利人:MAURO SANDRO; FATTORI DANIELA; D ANDREA PIERO; CIPOLLONE AMALIA; D ANDREA ENZO; ERCOLANO CARMELA; MENARINI INT OPERATIONS LU SA
摘要:The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.